Abstract
Compact carriers for peptidyl delivery systems (PDSs) loaded with various drugs were synthesized using a simple and convenient solid phase organic synthesis strategy, including semi-orthogonal functional group protection schemes. Each attachment point of the compact carrier can thus be bound to an anticancer agent through a biodegradable covalent link. Chemo- and biostability experiments of a model peptidyl platform loaded with three different drugs revealed pH and liver homogenate (metabolic) dependent sequential release behavior. The versatility of this approach will serve to expedite the preparation of PDS libraries. This approach may prove useful for applications suitable for personalized medicine where multiple drug delivery is required in a sequential and controlled fashion.
| Original language | English |
|---|---|
| Pages (from-to) | 119-132 |
| Number of pages | 14 |
| Journal | Biopolymers |
| Volume | 106 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1 Jan 2016 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- biostability
- chemostability
- drug delivery
- multiple drug delivery
- peptidyl delivery system
- prodrug
- sequential drug release
All Science Journal Classification (ASJC) codes
- Biophysics
- Biochemistry
- Biomaterials
- Organic Chemistry
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