Biointegrated Subtractive Microfabrication by Hydrodynamic Flow Confinement

Daniel Widerker; Federico Paratore; Govind Kaigala; Moran Bercovici

doi:https://doi.org/10.1109/MEMS46641.2020.9056368

Biointegrated Subtractive Microfabrication by Hydrodynamic Flow Confinement

Daniel Widerker, Federico Paratore, Govind Kaigala, Moran Bercovici

Mechanical Engineering

Technion - Israel Institute of Technology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

We present a new method that leverages hydrodynamic flow confinement to achieve both mechanical milling of micro-channels and patterning of biological molecules in a single process. We demonstrate applicability of the method through milling of a microchannel in polystyrene substrate through confinement of dichloromethane, followed by patterning of streptavidin in desired spots along the channel. This work is a first step toward our goal of achieving fully bio-integrated prototyping.

Original language	English
Title of host publication	33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020
Pages	102-105
Number of pages	4
ISBN (Electronic)	9781728135809
DOIs	https://doi.org/10.1109/MEMS46641.2020.9056368
State	Published - Jan 2020
Event	33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020 - Vancouver, Canada Duration: 18 Jan 2020 → 22 Jan 2020

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume	2020-January

Conference

Conference	33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020
Country/Territory	Canada
City	Vancouver
Period	18/01/20 → 22/01/20

Keywords

Microfluidics
bio patterning
biochips
flow confinement
in-vitro diagnostics
microfabrication
milling
open space

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Mechanical Engineering
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

https://doi.org/10.1109/MEMS46641.2020.9056368

Cite this

Widerker, D., Paratore, F., Kaigala, G., & Bercovici, M. (2020). Biointegrated Subtractive Microfabrication by Hydrodynamic Flow Confinement. In 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020 (pp. 102-105). Article 9056368 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2020-January). https://doi.org/10.1109/MEMS46641.2020.9056368

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title = "Biointegrated Subtractive Microfabrication by Hydrodynamic Flow Confinement",

abstract = "We present a new method that leverages hydrodynamic flow confinement to achieve both mechanical milling of micro-channels and patterning of biological molecules in a single process. We demonstrate applicability of the method through milling of a microchannel in polystyrene substrate through confinement of dichloromethane, followed by patterning of streptavidin in desired spots along the channel. This work is a first step toward our goal of achieving fully bio-integrated prototyping.",

keywords = "Microfluidics, bio patterning, biochips, flow confinement, in-vitro diagnostics, microfabrication, milling, open space",

author = "Daniel Widerker and Federico Paratore and Govind Kaigala and Moran Bercovici",

note = "Publisher Copyright: {\textcopyright} 2020 IEEE.; 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020 ; Conference date: 18-01-2020 Through 22-01-2020",

year = "2020",

month = jan,

doi = "https://doi.org/10.1109/MEMS46641.2020.9056368",

language = "الإنجليزيّة",

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booktitle = "33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020",

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Widerker, D, Paratore, F, Kaigala, G & Bercovici, M 2020, Biointegrated Subtractive Microfabrication by Hydrodynamic Flow Confinement. in 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020., 9056368, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), vol. 2020-January, pp. 102-105, 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020, Vancouver, Canada, 18/01/20. https://doi.org/10.1109/MEMS46641.2020.9056368

Biointegrated Subtractive Microfabrication by Hydrodynamic Flow Confinement. / Widerker, Daniel; Paratore, Federico; Kaigala, Govind et al.
33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020. 2020. p. 102-105 9056368 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2020-January).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Biointegrated Subtractive Microfabrication by Hydrodynamic Flow Confinement

AU - Widerker, Daniel

AU - Paratore, Federico

AU - Kaigala, Govind

AU - Bercovici, Moran

PY - 2020/1

Y1 - 2020/1

N2 - We present a new method that leverages hydrodynamic flow confinement to achieve both mechanical milling of micro-channels and patterning of biological molecules in a single process. We demonstrate applicability of the method through milling of a microchannel in polystyrene substrate through confinement of dichloromethane, followed by patterning of streptavidin in desired spots along the channel. This work is a first step toward our goal of achieving fully bio-integrated prototyping.

AB - We present a new method that leverages hydrodynamic flow confinement to achieve both mechanical milling of micro-channels and patterning of biological molecules in a single process. We demonstrate applicability of the method through milling of a microchannel in polystyrene substrate through confinement of dichloromethane, followed by patterning of streptavidin in desired spots along the channel. This work is a first step toward our goal of achieving fully bio-integrated prototyping.

KW - Microfluidics

KW - bio patterning

KW - biochips

KW - flow confinement

KW - in-vitro diagnostics

KW - microfabrication

KW - milling

KW - open space

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U2 - https://doi.org/10.1109/MEMS46641.2020.9056368

DO - https://doi.org/10.1109/MEMS46641.2020.9056368

M3 - منشور من مؤتمر

T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

SP - 102

EP - 105

BT - 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020

T2 - 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020

Y2 - 18 January 2020 through 22 January 2020

ER -

Widerker D, Paratore F, Kaigala G, Bercovici M. Biointegrated Subtractive Microfabrication by Hydrodynamic Flow Confinement. In 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020. 2020. p. 102-105. 9056368. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: https://doi.org/10.1109/MEMS46641.2020.9056368

Biointegrated Subtractive Microfabrication by Hydrodynamic Flow Confinement

Abstract

Publication series

Conference

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

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