Bio-amplifying lab-on-a-chip for antipsychotic clozapine treatment monitoring

H. Ben-Yoav, T. E. Winkler, S. E. Chocron, S. M. Restaino, G. R. Costa, E. Kim, D. L. Kelly, G. F. Payne, R. Ghodssi

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We present the first demonstration of an electrochemically-active biomaterial probe for schizophrenia treatment monitoring, and its integration in lab-on-a-chip devices. The probe consists of the naturally derived polymer, chitosan, grafted with catechol to provide a redox cycling system. These modifications to the probe significantly amplify the electrochemical signal generated by the antipsychotic drug clozapine, improving the signal-to-noise ratio and overall biosensing performance. The amplified signal generated by clozapine using the lab-on-a-chip with catechol-modified chitosan microelectrodes was 2.46-fold higher compared to unmodified microelectrodes. Additionally, human serum was tested to resemble future utilization in point-of-care analysis of schizophrenia patients.

Original languageAmerican English
Title of host publication2013 Transducers and Eurosensors XXVII
Subtitle of host publicationThe 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013
Pages317-320
Number of pages4
DOIs
StatePublished - 1 Dec 2013
Externally publishedYes
Event2013 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013 - Barcelona, Spain
Duration: 16 Jun 201320 Jun 2013

Publication series

Name2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013

Conference

Conference2013 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013
Country/TerritorySpain
CityBarcelona
Period16/06/1320/06/13

Keywords

  • Amplifier
  • Antipsychotic drug
  • Chitosan
  • Clozapine
  • Electrochemical biosensor
  • Redox cycling

All Science Journal Classification (ASJC) codes

  • Hardware and Architecture
  • Electrical and Electronic Engineering

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