@inproceedings{1f1c6d60d8e74699995c562afcd973c0,
title = "Bio-amplifying lab-on-a-chip for antipsychotic clozapine treatment monitoring",
abstract = "We present the first demonstration of an electrochemically-active biomaterial probe for schizophrenia treatment monitoring, and its integration in lab-on-a-chip devices. The probe consists of the naturally derived polymer, chitosan, grafted with catechol to provide a redox cycling system. These modifications to the probe significantly amplify the electrochemical signal generated by the antipsychotic drug clozapine, improving the signal-to-noise ratio and overall biosensing performance. The amplified signal generated by clozapine using the lab-on-a-chip with catechol-modified chitosan microelectrodes was 2.46-fold higher compared to unmodified microelectrodes. Additionally, human serum was tested to resemble future utilization in point-of-care analysis of schizophrenia patients.",
keywords = "Amplifier, Antipsychotic drug, Chitosan, Clozapine, Electrochemical biosensor, Redox cycling",
author = "H. Ben-Yoav and Winkler, {T. E.} and Chocron, {S. E.} and Restaino, {S. M.} and Costa, {G. R.} and E. Kim and Payne, {G. F.} and R. Ghodssi",
year = "2013",
month = dec,
day = "1",
doi = "https://doi.org/10.1109/Transducers.2013.6626766",
language = "English",
isbn = "9781467359818",
series = "2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013",
pages = "317--320",
booktitle = "2013 Transducers and Eurosensors XXVII",
note = "2013 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013 ; Conference date: 16-06-2013 Through 20-06-2013",
}