TY - JOUR
T1 - BCL-2 family proteins as regulators of mitochondria metabolism
AU - Gross, Atan
N1 - Studies in the laboratory of A.G. are supported in part by the Israel Science Foundation (ISF) (1002/15), USA-Israel Binational Science Foundation (BSF) (2009/093), German-Israel Foundation (GIF) (1106-70.11/2010), Minerva Stiftung (711422), MDM ICR Research award, Hyman T. Milgrom Trust, Rising Tide Trust, and the Merlo and Adelis Foundations. A.G. is the incumbent of the Marketa and Frederick Alexander Professional Chair.
PY - 2016/8
Y1 - 2016/8
N2 - The BCL-2 family proteins are major regulators of apoptosis, and one of their major sites of action are the mitochondria. Mitochondria are the cellular hubs for metabolism and indeed selected BCL-2 family proteins also possess roles related to mitochondria metabolism and dynamics. Here we discuss the link between mitochondrial metabolism/dynamics and the fate of stem cells, with an emphasis on the role of the BID-MTCH2 pair in regulating this link. We also discuss the possibility that BCL-2 family proteins act as metabolic sensors/messengers coming on and off of mitochondria to "sample" the cytosol and provide the mitochondria with up-to-date metabolic information. This article is part of a Special Issue entitled 'EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2-6, 2016', edited by Prof. Paolo Bernardi.
AB - The BCL-2 family proteins are major regulators of apoptosis, and one of their major sites of action are the mitochondria. Mitochondria are the cellular hubs for metabolism and indeed selected BCL-2 family proteins also possess roles related to mitochondria metabolism and dynamics. Here we discuss the link between mitochondrial metabolism/dynamics and the fate of stem cells, with an emphasis on the role of the BID-MTCH2 pair in regulating this link. We also discuss the possibility that BCL-2 family proteins act as metabolic sensors/messengers coming on and off of mitochondria to "sample" the cytosol and provide the mitochondria with up-to-date metabolic information. This article is part of a Special Issue entitled 'EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2-6, 2016', edited by Prof. Paolo Bernardi.
UR - http://www.scopus.com/inward/record.url?scp=84971408305&partnerID=8YFLogxK
U2 - 10.1016/j.bbabio.2016.01.017
DO - 10.1016/j.bbabio.2016.01.017
M3 - مقالة مرجعية
SN - 0005-2728
VL - 1857
SP - 1243
EP - 1246
JO - Biochimica et Biophysica Acta - Bioenergetics
JF - Biochimica et Biophysica Acta - Bioenergetics
IS - 8
ER -