B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches

Adi Biram; Eitan Winter; Alice E. Denton; Irina Zaretsky; Bareket Dassa; Mats Bemark; Michelle A. Linterman; Gur Yaari; Ziv Shulman

doi:10.1016/j.celrep.2020.01.032

B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches

Adi Biram, Eitan Winter, Alice E. Denton, Irina Zaretsky, Bareket Dassa, Mats Bemark, Michelle A. Linterman, Gur Yaari, Ziv Shulman

Bar-Ilan University - The Alexander Kofkin Faculty of Engineering

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

Abstract

SAP is required for proper T cell help in germinal centers (GCs). Biram et al. show that SAP-independent GCs are formed within Peyer's patches. These GCs host highly diversified clones that are subjected to mild selection forces, demonstrating that clonal diversification can be uncoupled from clonal selection in chronic GCs.

Original language	English
Pages (from-to)	1910-1922.e5
Journal	Cell Reports
Volume	30
Issue number	6
DOIs	https://doi.org/10.1016/j.celrep.2020.01.032
State	Published - 11 Feb 2020

Keywords

B cells
IgA
Peyer's patches
SAP
T follicular helper cells
antibody
clonal diversification
germinal center
plasma cells

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

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10.1016/j.celrep.2020.01.032

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title = "B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches",

abstract = "SAP is required for proper T cell help in germinal centers (GCs). Biram et al. show that SAP-independent GCs are formed within Peyer's patches. These GCs host highly diversified clones that are subjected to mild selection forces, demonstrating that clonal diversification can be uncoupled from clonal selection in chronic GCs.",

keywords = "B cells, IgA, Peyer's patches, SAP, T follicular helper cells, antibody, clonal diversification, germinal center, plasma cells",

author = "Adi Biram and Eitan Winter and Denton, \{Alice E.\} and Irina Zaretsky and Bareket Dassa and Mats Bemark and Linterman, \{Michelle A.\} and Gur Yaari and Ziv Shulman",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = feb,

day = "11",

doi = "10.1016/j.celrep.2020.01.032",

language = "الإنجليزيّة",

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T1 - B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches

AU - Biram, Adi

AU - Winter, Eitan

AU - Denton, Alice E.

AU - Zaretsky, Irina

AU - Dassa, Bareket

AU - Bemark, Mats

AU - Linterman, Michelle A.

AU - Yaari, Gur

AU - Shulman, Ziv

PY - 2020/2/11

Y1 - 2020/2/11

N2 - SAP is required for proper T cell help in germinal centers (GCs). Biram et al. show that SAP-independent GCs are formed within Peyer's patches. These GCs host highly diversified clones that are subjected to mild selection forces, demonstrating that clonal diversification can be uncoupled from clonal selection in chronic GCs.

AB - SAP is required for proper T cell help in germinal centers (GCs). Biram et al. show that SAP-independent GCs are formed within Peyer's patches. These GCs host highly diversified clones that are subjected to mild selection forces, demonstrating that clonal diversification can be uncoupled from clonal selection in chronic GCs.

KW - B cells

KW - IgA

KW - Peyer's patches

KW - SAP

KW - T follicular helper cells

KW - antibody

KW - clonal diversification

KW - germinal center

KW - plasma cells

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U2 - 10.1016/j.celrep.2020.01.032

DO - 10.1016/j.celrep.2020.01.032

M3 - مقالة

C2 - 32049020

SN - 2211-1247

VL - 30

SP - 1910-1922.e5

JO - Cell Reports

JF - Cell Reports

IS - 6

ER -

B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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