@article{cf641e5ba49a46edb2a3e420ad32d31b,
title = "Axonal transcription factors signal retrogradely in lesioned peripheral nerve",
abstract = "Retrograde axonal injury signalling stimulates cell body responses in lesioned peripheral neurons. The involvement of importins in retrograde transport suggests that transcription factors (TFs) might be directly involved in axonal injury signalling. Here, we show that multiple TFs are found in axons and associate with dynein in axoplasm from injured nerve. Biochemical and functional validation for one TF family establishes that axonal STAT3 is locally translated and activated upon injury, and is transported retrogradely with dynein and importin α5 to modulate survival of peripheral sensory neurons after injury. Hence, retrograde transport of TFs from axonal lesion sites provides a direct link between axon and nucleus.",
author = "Keren Ben-Yaakov and Dagan, {Shachar Y.} and Yael Segal-Ruder and Ophir Shalem and Deepika Vuppalanchi and Willis, {Dianna E.} and Dmitry Yudin and Ida Rishal and Franziska Rother and Michael Bader and Armin Blesch and Yitzhak Pilpel and Twiss, {Jeffery L.} and Mike Fainzilber",
note = "Israel Science Foundation [1157/09]; US-Israel Binational Science Foundation [2003208]; International Foundation for Research in Paraplegia [P86, P116]; Dr Miriam and Sheldon G Adelson Medical Research Foundation; German-Israeli Foundation [1010-168.1/2008]; Deutsche Forschungsgemeinschaft [KO 1950/3-1]; NIH [R01-NS041596, K99-NR010797]We gratefully thank Tal Gradus and Zehava Levy for technical assistance; and Eric Martz, Vladimir Kiss, Vera Shinder and Michael Tolmasov for expert assistance with structure modelling, fluorescence microscopy, electron microscopy, and microsurgery, respectively. We also thank Prof. Shizuo Akira for floxed-STAT3 mice; Alon Chen for the LV-Cre virus; and Michael Sofroniew for GFAP-STAT3-CKO mice. This work was supported by the Israel Science Foundation (1157/09), the US-Israel Binational Science Foundation (2003208), the International Foundation for Research in Paraplegia (P86 and P116), the Dr Miriam and Sheldon G Adelson Medical Research Foundation, the German-Israeli Foundation (1010-168.1/2008), the Deutsche Forschungsgemeinschaft (KO 1950/3-1); and the NIH (R01-NS041596 and K99-NR010797). MF is the incumbent of the Chaya Professorial Chair in Molecular Neuroscience at the Weizmann Institute of Science.",
year = "2012",
month = mar,
day = "21",
doi = "https://doi.org/10.1038/emboj.2011.494",
language = "الإنجليزيّة",
volume = "31",
pages = "1350--1363",
journal = "EMBO Journal",
issn = "0261-4189",
publisher = "EMBO Press",
number = "6",
}