Axonal and presynaptic FMRP: Localization, signal, and functional implications

Xiaoyu Wang; Dalit Sela-Donenfeld; Yuan Wang

doi:10.1016/j.heares.2023.108720

Axonal and presynaptic FMRP: Localization, signal, and functional implications

Xiaoyu Wang, Dalit Sela-Donenfeld, Yuan Wang

The Koret School of Veterinary Medicine

The Hebrew University of Jerusalem

Research output: Contribution to journal › Review article › peer-review

Abstract

Fragile X mental retardation protein (FMRP) binds a selected set of mRNAs and proteins to guide neural circuit assembly and regulate synaptic plasticity. Loss of FMRP is responsible for Fragile X syndrome, a neuropsychiatric disorder characterized with auditory processing problems and social difficulty. FMRP actions in synaptic formation, maturation, and plasticity are site-specific among the four compartments of a synapse: presynaptic and postsynaptic neurons, astrocytes, and extracellular matrix. This review summarizes advancements in understanding FMRP localization, signals, and functional roles in axons and presynaptic terminals.

Original language	English
Article number	108720
Journal	Hearing Research
Volume	430
DOIs	https://doi.org/10.1016/j.heares.2023.108720
State	Published - 15 Mar 2023

Keywords

Axon projection development
Axonal granules
Fragile X mental retardation protein
Neuropsychiatric disorders
Neurotransmitter release
RNA-binding proteins

All Science Journal Classification (ASJC) codes

Sensory Systems

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10.1016/j.heares.2023.108720

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title = "Axonal and presynaptic FMRP: Localization, signal, and functional implications",

abstract = "Fragile X mental retardation protein (FMRP) binds a selected set of mRNAs and proteins to guide neural circuit assembly and regulate synaptic plasticity. Loss of FMRP is responsible for Fragile X syndrome, a neuropsychiatric disorder characterized with auditory processing problems and social difficulty. FMRP actions in synaptic formation, maturation, and plasticity are site-specific among the four compartments of a synapse: presynaptic and postsynaptic neurons, astrocytes, and extracellular matrix. This review summarizes advancements in understanding FMRP localization, signals, and functional roles in axons and presynaptic terminals.",

keywords = "Axon projection development, Axonal granules, Fragile X mental retardation protein, Neuropsychiatric disorders, Neurotransmitter release, RNA-binding proteins",

author = "Xiaoyu Wang and Dalit Sela-Donenfeld and Yuan Wang",

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year = "2023",

month = mar,

day = "15",

doi = "10.1016/j.heares.2023.108720",

language = "الإنجليزيّة",

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TY - JOUR

T1 - Axonal and presynaptic FMRP

T2 - Localization, signal, and functional implications

AU - Wang, Xiaoyu

AU - Sela-Donenfeld, Dalit

AU - Wang, Yuan

PY - 2023/3/15

Y1 - 2023/3/15

N2 - Fragile X mental retardation protein (FMRP) binds a selected set of mRNAs and proteins to guide neural circuit assembly and regulate synaptic plasticity. Loss of FMRP is responsible for Fragile X syndrome, a neuropsychiatric disorder characterized with auditory processing problems and social difficulty. FMRP actions in synaptic formation, maturation, and plasticity are site-specific among the four compartments of a synapse: presynaptic and postsynaptic neurons, astrocytes, and extracellular matrix. This review summarizes advancements in understanding FMRP localization, signals, and functional roles in axons and presynaptic terminals.

AB - Fragile X mental retardation protein (FMRP) binds a selected set of mRNAs and proteins to guide neural circuit assembly and regulate synaptic plasticity. Loss of FMRP is responsible for Fragile X syndrome, a neuropsychiatric disorder characterized with auditory processing problems and social difficulty. FMRP actions in synaptic formation, maturation, and plasticity are site-specific among the four compartments of a synapse: presynaptic and postsynaptic neurons, astrocytes, and extracellular matrix. This review summarizes advancements in understanding FMRP localization, signals, and functional roles in axons and presynaptic terminals.

KW - Axon projection development

KW - Axonal granules

KW - Fragile X mental retardation protein

KW - Neuropsychiatric disorders

KW - Neurotransmitter release

KW - RNA-binding proteins

UR - http://www.scopus.com/inward/record.url?scp=85148338149&partnerID=8YFLogxK

U2 - 10.1016/j.heares.2023.108720

DO - 10.1016/j.heares.2023.108720

M3 - مقالة مرجعية

C2 - 36809742

SN - 0378-5955

VL - 430

JO - Hearing Research

JF - Hearing Research

M1 - 108720

ER -

Axonal and presynaptic FMRP: Localization, signal, and functional implications

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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