Autophagy in adipose tissue and the beta cell: Implications for obesity and diabetes

Rinke Stienstra; Yulia Haim; Yael Riahi; Mihai Netea; Assaf Rudich; Gil Leibowitz

doi:10.1007/s00125-014-3255-3

Autophagy in adipose tissue and the beta cell: Implications for obesity and diabetes

Rinke Stienstra, Yulia Haim, Yael Riahi, Mihai Netea, Assaf Rudich, Gil Leibowitz

Department of Clinical Biochemistry and Pharmacology

Ben-Gurion University of the Negev

Research output: Contribution to journal › Review article › peer-review

Abstract

Autophagy is a lysosomal degradation pathway recycling intracellular long-lived proteins and damaged organelles, thereby maintaining cellular homeostasis. In addition to inflammatory processes, autophagy has been implicated in the regulation of adipose tissue and beta cell functions. In obesity and type 2 diabetes autophagic activity is modulated in a tissue-dependent manner. In this review we discuss the regulation of autophagy in adipose tissue and beta cells, exemplifying tissue-specific dysregulation of autophagy and its implications for the pathophysiology of obesity and type 2 diabetes. We will highlight common themes and outstanding gaps in our understanding, which need to be addressed before autophagy could be envisioned as a therapeutic target for the treatment of obesity and diabetes.

Original language	American English
Pages (from-to)	1505-1516
Number of pages	12
Journal	Diabetologia
Volume	57
Issue number	8
DOIs	https://doi.org/10.1007/s00125-014-3255-3
State	Published - 1 Jan 2014

Keywords

Adipocyte
Adipose tissue
Apoptosis
Autophagy
Beta cell
Diabetes
ER stress
Inflammation
Insulin resistance
Macrophage
Obesity

All Science Journal Classification (ASJC) codes

Internal Medicine
Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00125-014-3255-3

Cite this

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title = "Autophagy in adipose tissue and the beta cell: Implications for obesity and diabetes",

abstract = "Autophagy is a lysosomal degradation pathway recycling intracellular long-lived proteins and damaged organelles, thereby maintaining cellular homeostasis. In addition to inflammatory processes, autophagy has been implicated in the regulation of adipose tissue and beta cell functions. In obesity and type 2 diabetes autophagic activity is modulated in a tissue-dependent manner. In this review we discuss the regulation of autophagy in adipose tissue and beta cells, exemplifying tissue-specific dysregulation of autophagy and its implications for the pathophysiology of obesity and type 2 diabetes. We will highlight common themes and outstanding gaps in our understanding, which need to be addressed before autophagy could be envisioned as a therapeutic target for the treatment of obesity and diabetes.",

keywords = "Adipocyte, Adipose tissue, Apoptosis, Autophagy, Beta cell, Diabetes, ER stress, Inflammation, Insulin resistance, Macrophage, Obesity",

author = "Rinke Stienstra and Yulia Haim and Yael Riahi and Mihai Netea and Assaf Rudich and Gil Leibowitz",

note = "Funding Information: Funding This work was supported by grants from Deutsche Forschungsgemeinschaft (DFG): SFB 1052/1: {\textquoteleft}Obesity mechanisms{\textquoteright} (project B02, to AR) and by the Israel Science Foundation (347/12) to GL. RS is supported by a VIDI-grant from the Netherlands Organization for Scientific Research (NWO).",

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doi = "10.1007/s00125-014-3255-3",

language = "American English",

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T1 - Autophagy in adipose tissue and the beta cell

T2 - Implications for obesity and diabetes

AU - Stienstra, Rinke

AU - Haim, Yulia

AU - Riahi, Yael

AU - Netea, Mihai

AU - Rudich, Assaf

AU - Leibowitz, Gil

N1 - Funding Information: Funding This work was supported by grants from Deutsche Forschungsgemeinschaft (DFG): SFB 1052/1: ‘Obesity mechanisms’ (project B02, to AR) and by the Israel Science Foundation (347/12) to GL. RS is supported by a VIDI-grant from the Netherlands Organization for Scientific Research (NWO).

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Autophagy is a lysosomal degradation pathway recycling intracellular long-lived proteins and damaged organelles, thereby maintaining cellular homeostasis. In addition to inflammatory processes, autophagy has been implicated in the regulation of adipose tissue and beta cell functions. In obesity and type 2 diabetes autophagic activity is modulated in a tissue-dependent manner. In this review we discuss the regulation of autophagy in adipose tissue and beta cells, exemplifying tissue-specific dysregulation of autophagy and its implications for the pathophysiology of obesity and type 2 diabetes. We will highlight common themes and outstanding gaps in our understanding, which need to be addressed before autophagy could be envisioned as a therapeutic target for the treatment of obesity and diabetes.

AB - Autophagy is a lysosomal degradation pathway recycling intracellular long-lived proteins and damaged organelles, thereby maintaining cellular homeostasis. In addition to inflammatory processes, autophagy has been implicated in the regulation of adipose tissue and beta cell functions. In obesity and type 2 diabetes autophagic activity is modulated in a tissue-dependent manner. In this review we discuss the regulation of autophagy in adipose tissue and beta cells, exemplifying tissue-specific dysregulation of autophagy and its implications for the pathophysiology of obesity and type 2 diabetes. We will highlight common themes and outstanding gaps in our understanding, which need to be addressed before autophagy could be envisioned as a therapeutic target for the treatment of obesity and diabetes.

KW - Adipocyte

KW - Adipose tissue

KW - Apoptosis

KW - Autophagy

KW - Beta cell

KW - Diabetes

KW - ER stress

KW - Inflammation

KW - Insulin resistance

KW - Macrophage

KW - Obesity

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U2 - 10.1007/s00125-014-3255-3

DO - 10.1007/s00125-014-3255-3

M3 - Review article

C2 - 24795087

SN - 0012-186X

VL - 57

SP - 1505

EP - 1516

JO - Diabetologia

JF - Diabetologia

IS - 8

ER -

Autophagy in adipose tissue and the beta cell: Implications for obesity and diabetes

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

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