Abstract
Sialic acid-containing glycans play a major role in cell-surface interactions with external partners such as cells and viruses. Straightforward access to sialosides is required in order to study their biological functions on a molecular level. Here, automated oligosaccharide synthesis was used to facilitate the preparation of this class of biomolecules. Our strategy relies on novel sialyl α-(2→3) and α-(2→6) galactosyl imidates, which, used in combination with the automated platform, provided rapid access to a small library of conjugation-ready sialosides of biological relevance.
Original language | English |
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Pages (from-to) | 1601-1609 |
Number of pages | 9 |
Journal | Beilstein Journal of Organic Chemistry |
Volume | 8 |
DOIs | |
State | Published - 21 Sep 2012 |
Externally published | Yes |
Keywords
- Automated synthesis
- Disaccharide building blocks
- Sialic acid
- Sialosides
- Solid-phase synthesis
All Science Journal Classification (ASJC) codes
- Organic Chemistry