ATX restricts anti-tumor eosinophil responses

Sharon Grisaru-Tal; Ariel Munitz

doi:10.1038/s43018-023-00718-5

ATX restricts anti-tumor eosinophil responses

Sharon Grisaru-Tal, Ariel Munitz

Clinical Microbiology and Immunology

Tel Aviv University

Research output: Contribution to journal › Comment/debate

Abstract

Autotaxin (ATX) produces lysophosphatidic acid (LPA), which directly promotes pancreatic ductal adenocarcinoma (PDAC) growth, but the role of the tumor microenvironment (TME) in ATX-driven tumor growth is unclear. ATX–LPA signaling in PDAC is now shown to shape the TME by inhibiting eosinophil recruitment, resulting in increased tumor growth.

Original language	English
Pages (from-to)	221-223
Number of pages	3
Journal	Nature Cancer
Volume	5
Issue number	2
DOIs	https://doi.org/10.1038/s43018-023-00718-5
State	Published - Feb 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1038/s43018-023-00718-5

Cite this

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title = "ATX restricts anti-tumor eosinophil responses",

abstract = "Autotaxin (ATX) produces lysophosphatidic acid (LPA), which directly promotes pancreatic ductal adenocarcinoma (PDAC) growth, but the role of the tumor microenvironment (TME) in ATX-driven tumor growth is unclear. ATX–LPA signaling in PDAC is now shown to shape the TME by inhibiting eosinophil recruitment, resulting in increased tumor growth.",

author = "Sharon Grisaru-Tal and Ariel Munitz",

note = "Publisher Copyright: {\textcopyright} Springer Nature America, Inc 2024.",

year = "2024",

month = feb,

doi = "10.1038/s43018-023-00718-5",

language = "الإنجليزيّة",

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journal = "Nature Cancer",

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AU - Grisaru-Tal, Sharon

AU - Munitz, Ariel

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N2 - Autotaxin (ATX) produces lysophosphatidic acid (LPA), which directly promotes pancreatic ductal adenocarcinoma (PDAC) growth, but the role of the tumor microenvironment (TME) in ATX-driven tumor growth is unclear. ATX–LPA signaling in PDAC is now shown to shape the TME by inhibiting eosinophil recruitment, resulting in increased tumor growth.

AB - Autotaxin (ATX) produces lysophosphatidic acid (LPA), which directly promotes pancreatic ductal adenocarcinoma (PDAC) growth, but the role of the tumor microenvironment (TME) in ATX-driven tumor growth is unclear. ATX–LPA signaling in PDAC is now shown to shape the TME by inhibiting eosinophil recruitment, resulting in increased tumor growth.

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U2 - 10.1038/s43018-023-00718-5

DO - 10.1038/s43018-023-00718-5

M3 - تعليقَ / نقاش

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SN - 1474-175X

VL - 5

SP - 221

EP - 223

JO - Nature Cancer

JF - Nature Cancer

IS - 2

ER -

ATX restricts anti-tumor eosinophil responses

Abstract

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All Science Journal Classification (ASJC) codes

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