Asymmetric Copper-Catalyzed Carbomagnesiation of Cyclopropenes

Longyang Dian; Daniel S. Mueller; Ilan Marek; Daniel S. Müller

doi:10.1002/anie.201701094

Asymmetric Copper-Catalyzed Carbomagnesiation of Cyclopropenes

Longyang Dian, Daniel S. Mueller, Ilan Marek, Daniel S. Müller

Technion - Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

The highly diastereo- and enantioselective formation of polysubstituted cyclopropanes was easily achieved through the asymmetric copper-catalyzed carbomagnesiation reaction of nonfunctionalized cyclopropene derivatives. The carbometalated species generated in situ readily undergo C−C and C−X bond-forming reactions with various electrophiles with complete retention of configuration.

Original language	English
Pages (from-to)	6783-6787
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	56
Issue number	24
DOIs	https://doi.org/10.1002/anie.201701094
State	Published - 6 Jun 2017

Keywords

asymmetric catalysis
carbometalation
configurational stability
cyclopropanes
cyclopropenes

All Science Journal Classification (ASJC) codes

Catalysis
General Chemistry

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10.1002/anie.201701094

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title = "Asymmetric Copper-Catalyzed Carbomagnesiation of Cyclopropenes",

abstract = "The highly diastereo- and enantioselective formation of polysubstituted cyclopropanes was easily achieved through the asymmetric copper-catalyzed carbomagnesiation reaction of nonfunctionalized cyclopropene derivatives. The carbometalated species generated in situ readily undergo C−C and C−X bond-forming reactions with various electrophiles with complete retention of configuration.",

keywords = "asymmetric catalysis, carbometalation, configurational stability, cyclopropanes, cyclopropenes",

author = "Longyang Dian and Mueller, \{Daniel S.\} and Ilan Marek and M{\"u}ller, \{Daniel S.\}",

note = "Publisher Copyright: {\textcopyright} 2017 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2017",

month = jun,

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doi = "10.1002/anie.201701094",

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T1 - Asymmetric Copper-Catalyzed Carbomagnesiation of Cyclopropenes

AU - Dian, Longyang

AU - Mueller, Daniel S.

AU - Marek, Ilan

AU - Müller, Daniel S.

PY - 2017/6/6

Y1 - 2017/6/6

N2 - The highly diastereo- and enantioselective formation of polysubstituted cyclopropanes was easily achieved through the asymmetric copper-catalyzed carbomagnesiation reaction of nonfunctionalized cyclopropene derivatives. The carbometalated species generated in situ readily undergo C−C and C−X bond-forming reactions with various electrophiles with complete retention of configuration.

AB - The highly diastereo- and enantioselective formation of polysubstituted cyclopropanes was easily achieved through the asymmetric copper-catalyzed carbomagnesiation reaction of nonfunctionalized cyclopropene derivatives. The carbometalated species generated in situ readily undergo C−C and C−X bond-forming reactions with various electrophiles with complete retention of configuration.

KW - asymmetric catalysis

KW - carbometalation

KW - configurational stability

KW - cyclopropanes

KW - cyclopropenes

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U2 - 10.1002/anie.201701094

DO - 10.1002/anie.201701094

M3 - مقالة

SN - 1433-7851

VL - 56

SP - 6783

EP - 6787

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 24

ER -

Asymmetric Copper-Catalyzed Carbomagnesiation of Cyclopropenes

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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