Asymmetric Copper-Catalyzed Carbomagnesiation of Cyclopropenes

Longyang Dian, Daniel S. Mueller, Ilan Marek, Daniel S. Müller

Research output: Contribution to journalArticlepeer-review

Abstract

The highly diastereo- and enantioselective formation of polysubstituted cyclopropanes was easily achieved through the asymmetric copper-catalyzed carbomagnesiation reaction of nonfunctionalized cyclopropene derivatives. The carbometalated species generated in situ readily undergo C−C and C−X bond-forming reactions with various electrophiles with complete retention of configuration.

Original languageEnglish
Pages (from-to)6783-6787
Number of pages5
JournalAngewandte Chemie - International Edition
Volume56
Issue number24
DOIs
StatePublished - 6 Jun 2017

Keywords

  • asymmetric catalysis
  • carbometalation
  • configurational stability
  • cyclopropanes
  • cyclopropenes

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Catalysis

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