Asymmetric Catalytic Preparation of Polysubstituted Cyclopropanol and Cyclopropylamine Derivatives

Marwan Simaan; Ilan Marek

doi:10.1002/anie.201710707

Asymmetric Catalytic Preparation of Polysubstituted Cyclopropanol and Cyclopropylamine Derivatives

Marwan Simaan, Ilan Marek

Technion - Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

The catalytic asymmetric carbometalation of cyclopropenes followed by either an electrophilic oxidation or amination reaction provides a unique approach to the formation of diastereomerically pure and enantiomerically enriched cyclopropanol and cyclopropylamine derivatives, respectively.

Original language	English
Pages (from-to)	1543-1546
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	57
Issue number	6
DOIs	https://doi.org/10.1002/anie.201710707
State	Published - 5 Feb 2018

Keywords

amination
carbometalation
cyclopropanols
cyclopropylamines
oxidation

All Science Journal Classification (ASJC) codes

Catalysis
General Chemistry

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10.1002/anie.201710707

Cite this

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title = "Asymmetric Catalytic Preparation of Polysubstituted Cyclopropanol and Cyclopropylamine Derivatives",

abstract = "The catalytic asymmetric carbometalation of cyclopropenes followed by either an electrophilic oxidation or amination reaction provides a unique approach to the formation of diastereomerically pure and enantiomerically enriched cyclopropanol and cyclopropylamine derivatives, respectively.",

keywords = "amination, carbometalation, cyclopropanols, cyclopropylamines, oxidation",

author = "Marwan Simaan and Ilan Marek",

note = "Publisher Copyright: {\textcopyright} 2018 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2018",

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doi = "10.1002/anie.201710707",

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T1 - Asymmetric Catalytic Preparation of Polysubstituted Cyclopropanol and Cyclopropylamine Derivatives

AU - Simaan, Marwan

AU - Marek, Ilan

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N2 - The catalytic asymmetric carbometalation of cyclopropenes followed by either an electrophilic oxidation or amination reaction provides a unique approach to the formation of diastereomerically pure and enantiomerically enriched cyclopropanol and cyclopropylamine derivatives, respectively.

AB - The catalytic asymmetric carbometalation of cyclopropenes followed by either an electrophilic oxidation or amination reaction provides a unique approach to the formation of diastereomerically pure and enantiomerically enriched cyclopropanol and cyclopropylamine derivatives, respectively.

KW - amination

KW - carbometalation

KW - cyclopropanols

KW - cyclopropylamines

KW - oxidation

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U2 - 10.1002/anie.201710707

DO - 10.1002/anie.201710707

M3 - مقالة

SN - 1433-7851

VL - 57

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EP - 1546

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 6

ER -

Asymmetric Catalytic Preparation of Polysubstituted Cyclopropanol and Cyclopropylamine Derivatives

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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