TY - JOUR
T1 - Associations Between Mid-Life Psychosocial Measures and Estimated Late Life Amyloid Burden
T2 - The Atherosclerosis Risk in Communities (ARIC)-PET Study
AU - Groechel, Renee C.
AU - Liu, Albert C.
AU - Koton, Silvia
AU - Kucharska-Newton, Anna M.
AU - Lutsey, Pamela L.
AU - Mosley, Thomas H.
AU - Palta, Priya
AU - Richey Sharrett, A.
AU - Walker, Keenan A.
AU - Wong, Dean F.
AU - Gottesman, Rebecca F.
N1 - Publisher Copyright: © 2024 – IOS Press. All rights reserved.
PY - 2024/2/13
Y1 - 2024/2/13
N2 - Background: Psychosocial factors are modifiable risk factors for Alzheimer’s disease (AD). One mechanism linking psychosocial factors to AD risk may be through biological measures of brain amyloid; however, this association has not been widely studied. Objective: To determine if mid-life measures of social support and social isolation in the Atherosclerosis Risk in Communities (ARIC) Study cohort are associated with late life brain amyloid burden, measured using florbetapir positron emission tomography (PET). Methods: Measures of social support and social isolation were assessed in ARIC participants (visit 2: 1990–1992). Brain amyloid was evaluated with florbetapir PET standardized uptake value ratios (SUVRs; visit 5: 2012–2014). Results: Among 316 participants without dementia, participants with intermediate (odds ratio (OR), 0.47; 95% CI, 0.25–0.88), or low social support (OR, 0.43; 95% CI, 0.22–0.83) in mid-life were less likely to have elevated amyloid SUVRs, relative to participants with high social support. Participants with moderate risk for social isolation in mid-life (OR, 0.32; 95% CI, 0.14–0.74) were less likely to have elevated amyloid burden than participants at low risk for social isolation. These associations were not significantly modified by sex or race. Conclusions: Lower social support and moderate risk of social isolation in mid-life were associated with lower odds of elevated amyloid SUVR in late life, compared to participants with greater mid-life psychosocial measures. Future longitudinal studies evaluating mid-life psychosocial factors, in relation to brain amyloid as well as other health outcomes, will strengthen our understanding of the role of these factors throughout the lifetime.
AB - Background: Psychosocial factors are modifiable risk factors for Alzheimer’s disease (AD). One mechanism linking psychosocial factors to AD risk may be through biological measures of brain amyloid; however, this association has not been widely studied. Objective: To determine if mid-life measures of social support and social isolation in the Atherosclerosis Risk in Communities (ARIC) Study cohort are associated with late life brain amyloid burden, measured using florbetapir positron emission tomography (PET). Methods: Measures of social support and social isolation were assessed in ARIC participants (visit 2: 1990–1992). Brain amyloid was evaluated with florbetapir PET standardized uptake value ratios (SUVRs; visit 5: 2012–2014). Results: Among 316 participants without dementia, participants with intermediate (odds ratio (OR), 0.47; 95% CI, 0.25–0.88), or low social support (OR, 0.43; 95% CI, 0.22–0.83) in mid-life were less likely to have elevated amyloid SUVRs, relative to participants with high social support. Participants with moderate risk for social isolation in mid-life (OR, 0.32; 95% CI, 0.14–0.74) were less likely to have elevated amyloid burden than participants at low risk for social isolation. These associations were not significantly modified by sex or race. Conclusions: Lower social support and moderate risk of social isolation in mid-life were associated with lower odds of elevated amyloid SUVR in late life, compared to participants with greater mid-life psychosocial measures. Future longitudinal studies evaluating mid-life psychosocial factors, in relation to brain amyloid as well as other health outcomes, will strengthen our understanding of the role of these factors throughout the lifetime.
KW - Alzheimer’s disease
KW - amyloid-beta
KW - dementia
KW - mid-life
KW - positron emission tomography
KW - psychosocial factors
UR - http://www.scopus.com/inward/record.url?scp=85185344169&partnerID=8YFLogxK
U2 - https://doi.org/10.3233/JAD-231218
DO - https://doi.org/10.3233/JAD-231218
M3 - مقالة
C2 - 38339934
SN - 1387-2877
VL - 97
SP - 1901
EP - 1911
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 4
ER -