Association of serotype-specific antibody concentrations and functional antibody titers with subsequent pneumococcal carriage in toddlers immunized with a 9-valent pneumococcal conjugate vaccine

Birgit Simell; Anu Nurkka; Mika Lahdenkari; Noga Givon-Lavi; Helena Käyhty; Ron Dagan; Jukka Jokinena

doi:10.1128/CVI.05369-11

Association of serotype-specific antibody concentrations and functional antibody titers with subsequent pneumococcal carriage in toddlers immunized with a 9-valent pneumococcal conjugate vaccine

Birgit Simell, Anu Nurkka, Mika Lahdenkari, Noga Givon-Lavi, Helena Käyhty, Ron Dagan, Jukka Jokinena

Ben-Gurion University of the Negev

Research output: Contribution to journal › Article › peer-review

Abstract

Association of pneumococcal nasopharyngeal carriage with the concentration and opsonophagocytic activity (OPA) of serum serotype-specific antibodies was determined for toddlers 1 month after immunization with a 9-valent pneumococcal conjugate vaccine. Higher anti-serotype 14 and anti-serotype 19F IgG and anti-serotype 14 IgM correlated with a lowered probability of pneumococcal acquisition. Postvaccination OPA did not correlate with pneumococcal carriage.

Original language	English
Pages (from-to)	96-99
Number of pages	4
Journal	Clinical and Vaccine Immunology
Volume	19
Issue number	1
DOIs	https://doi.org/10.1128/CVI.05369-11
State	Published - 1 Jan 2012

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Clinical Biochemistry
Immunology and Allergy
Immunology

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10.1128/CVI.05369-11

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Simell, B., Nurkka, A., Lahdenkari, M., Givon-Lavi, N., Käyhty, H., Dagan, R., & Jokinena, J. (2012). Association of serotype-specific antibody concentrations and functional antibody titers with subsequent pneumococcal carriage in toddlers immunized with a 9-valent pneumococcal conjugate vaccine. Clinical and Vaccine Immunology, 19(1), 96-99. https://doi.org/10.1128/CVI.05369-11

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abstract = "Association of pneumococcal nasopharyngeal carriage with the concentration and opsonophagocytic activity (OPA) of serum serotype-specific antibodies was determined for toddlers 1 month after immunization with a 9-valent pneumococcal conjugate vaccine. Higher anti-serotype 14 and anti-serotype 19F IgG and anti-serotype 14 IgM correlated with a lowered probability of pneumococcal acquisition. Postvaccination OPA did not correlate with pneumococcal carriage.",

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Simell, B, Nurkka, A, Lahdenkari, M, Givon-Lavi, N, Käyhty, H, Dagan, R & Jokinena, J 2012, 'Association of serotype-specific antibody concentrations and functional antibody titers with subsequent pneumococcal carriage in toddlers immunized with a 9-valent pneumococcal conjugate vaccine', Clinical and Vaccine Immunology, vol. 19, no. 1, pp. 96-99. https://doi.org/10.1128/CVI.05369-11

Association of serotype-specific antibody concentrations and functional antibody titers with subsequent pneumococcal carriage in toddlers immunized with a 9-valent pneumococcal conjugate vaccine. / Simell, Birgit; Nurkka, Anu; Lahdenkari, Mika et al.
In: Clinical and Vaccine Immunology, Vol. 19, No. 1, 01.01.2012, p. 96-99.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Association of serotype-specific antibody concentrations and functional antibody titers with subsequent pneumococcal carriage in toddlers immunized with a 9-valent pneumococcal conjugate vaccine

AU - Simell, Birgit

AU - Nurkka, Anu

AU - Lahdenkari, Mika

AU - Givon-Lavi, Noga

AU - Käyhty, Helena

AU - Dagan, Ron

AU - Jokinena, Jukka

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AB - Association of pneumococcal nasopharyngeal carriage with the concentration and opsonophagocytic activity (OPA) of serum serotype-specific antibodies was determined for toddlers 1 month after immunization with a 9-valent pneumococcal conjugate vaccine. Higher anti-serotype 14 and anti-serotype 19F IgG and anti-serotype 14 IgM correlated with a lowered probability of pneumococcal acquisition. Postvaccination OPA did not correlate with pneumococcal carriage.

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U2 - 10.1128/CVI.05369-11

DO - 10.1128/CVI.05369-11

M3 - مقالة

C2 - 22072724

SN - 1556-6811

VL - 19

SP - 96

EP - 99

JO - Clinical and Vaccine Immunology

JF - Clinical and Vaccine Immunology

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ER -

Association of serotype-specific antibody concentrations and functional antibody titers with subsequent pneumococcal carriage in toddlers immunized with a 9-valent pneumococcal conjugate vaccine

Abstract

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