Assigning the Algal Source of Dimethylsulfide Using a Selective Lyase Inhibitor

Uria Alcolombri; Lei Lei; Diana Meltzer; Assaf Vardi; Dan Tawfik

doi:https://doi.org/10.1021/acschembio.6b00844

Assigning the Algal Source of Dimethylsulfide Using a Selective Lyase Inhibitor

Uria Alcolombri, Lei Lei, Diana Meltzer, Assaf Vardi, Dan Tawfik

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

Atmospheric dimethylsulfide (DMS) is massively produced in the oceans by bacteria, algae, and corals. To enable identification of DMS sources, we developed a potent mechanism-based inhibitor of the algal Alma dimethylsulfoniopropionate lyase family that does not inhibit known bacterial lyases. Its application to coral holobiont indicates that DMS originates from Alma lyase(s). This biochemical profiling may complement meta-genomics and transcriptomics to provide better understanding of the marine sulfur Cycle.

Original language	English
Pages (from-to)	41-46
Number of pages	6
Journal	ACS Chemical Biology
Volume	12
Issue number	1
Early online date	6 Dec 2016
DOIs	https://doi.org/10.1021/acschembio.6b00844
State	Published - 20 Jan 2017

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abstract = "Atmospheric dimethylsulfide (DMS) is massively produced in the oceans by bacteria, algae, and corals. To enable identification of DMS sources, we developed a potent mechanism-based inhibitor of the algal Alma dimethylsulfoniopropionate lyase family that does not inhibit known bacterial lyases. Its application to coral holobiont indicates that DMS originates from Alma lyase(s). This biochemical profiling may complement meta-genomics and transcriptomics to provide better understanding of the marine sulfur Cycle.",

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AU - Tawfik, Dan

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AB - Atmospheric dimethylsulfide (DMS) is massively produced in the oceans by bacteria, algae, and corals. To enable identification of DMS sources, we developed a potent mechanism-based inhibitor of the algal Alma dimethylsulfoniopropionate lyase family that does not inhibit known bacterial lyases. Its application to coral holobiont indicates that DMS originates from Alma lyase(s). This biochemical profiling may complement meta-genomics and transcriptomics to provide better understanding of the marine sulfur Cycle.

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Assigning the Algal Source of Dimethylsulfide Using a Selective Lyase Inhibitor

Abstract

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