Assessment of Endogenous Pain-Inhibition Processes Through the Conditioned Pain Modulation (CPM) and the Offset Analgesia Paradigms

Roi Treister, David Yarnitsky, Yelena Granovsky

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Conditioned pain modulation (CPM) and offset analgesia (OA) are two psychophysical paradigms used for the assessment of endogenous pain modulation. Their mode of action is based on spatial and temporal filtering of nociceptive information, respectively, via activation of pain inhibitory mechanisms. Despite distinct brain mechanisms, both responses are deficient in patients with chronic pain. The CPM response had been proven for the prediction of pain acquisition and pain treatment success.

Original languageAmerican English
Title of host publicationThe Senses
Subtitle of host publicationA Comprehensive Reference: Volume 1-7, Second Edition
EditorsBernd Fritzsch
PublisherElsevier
Pages791-800
Number of pages10
Volume5
ISBN (Electronic)9780128054093
ISBN (Print)9780128054086
DOIs
StatePublished - 1 Jan 2020

Keywords

  • Chronic pain
  • Clinical relevance
  • Conditioned pain modulation
  • Endogenous analgesia
  • Mechanisms
  • Methodology
  • Offset analgesia
  • Pain
  • Pain facilitation
  • Pain inhibition

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • General Medicine

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