ARTS, the unusual septin: Structural and functional aspects

Yael Mandel-Gutfreund; Idit Kosti; Sarit Larisch

doi:10.1515/BC.2011.089

ARTS, the unusual septin: Structural and functional aspects

Yael Mandel-Gutfreund, Idit Kosti, Sarit Larisch

Technion - Israel Institute of Technology, University of Haifa

Research output: Contribution to journal › Article › peer-review

Abstract

The human Septin 4 gene (Sept4) encodes two major protein isoforms; Sept4-i1 (H5/PNUTL2) and Sept4-i2/ARTS. Septins have been traditionally studied for their role in cytokinesis and their filament-forming abilities, but subsequently have been implicated in diverse functions, including membrane dynamics, cytoskeletal reorganization, vesicle trafficking, and tumorigenesis. ARTS is localized at mitochondria and promotes programmed cell death (apoptosis). These features distinguish ARTS from any other known human septin family member. This review compares the structural and functional properties of ARTS with other septins. In addition, it describes how a combination of two distinct promoters, differential splicing, and intron retention leads to the generation of two different Sept4 variants with diverse biological activity.

Original language	English
Pages (from-to)	783-790
Number of pages	8
Journal	Biological Chemistry
Volume	392
Issue number	8-9
DOIs	https://doi.org/10.1515/BC.2011.089
State	Published - 1 Aug 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

ARTS
Sept4
XIAP
apoptosis
mitochondria
tumor suppressor protein

All Science Journal Classification (ASJC) codes

Molecular Biology
Biochemistry
Clinical Biochemistry

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10.1515/BC.2011.089

Cite this

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title = "ARTS, the unusual septin: Structural and functional aspects",

abstract = "The human Septin 4 gene (Sept4) encodes two major protein isoforms; Sept4-i1 (H5/PNUTL2) and Sept4-i2/ARTS. Septins have been traditionally studied for their role in cytokinesis and their filament-forming abilities, but subsequently have been implicated in diverse functions, including membrane dynamics, cytoskeletal reorganization, vesicle trafficking, and tumorigenesis. ARTS is localized at mitochondria and promotes programmed cell death (apoptosis). These features distinguish ARTS from any other known human septin family member. This review compares the structural and functional properties of ARTS with other septins. In addition, it describes how a combination of two distinct promoters, differential splicing, and intron retention leads to the generation of two different Sept4 variants with diverse biological activity.",

keywords = "ARTS, Sept4, XIAP, apoptosis, mitochondria, tumor suppressor protein",

author = "Yael Mandel-Gutfreund and Idit Kosti and Sarit Larisch",

note = "Funding Information: We are very grateful to Hermann Steller for critical reading of the manuscript and to Juliana Kagan for technical assistance. Work from SL{\textquoteright}s laboratory described in this review was supported by funds from US Israel Binational Science Foundation grant 2003085 (to SL), Israel Science Foundation grant 1264/06 (to SL), and a grant from Israel Cancer Association (to SL).",

year = "2011",

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doi = "10.1515/BC.2011.089",

language = "الإنجليزيّة",

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T2 - Structural and functional aspects

AU - Mandel-Gutfreund, Yael

AU - Kosti, Idit

AU - Larisch, Sarit

N1 - Funding Information: We are very grateful to Hermann Steller for critical reading of the manuscript and to Juliana Kagan for technical assistance. Work from SL’s laboratory described in this review was supported by funds from US Israel Binational Science Foundation grant 2003085 (to SL), Israel Science Foundation grant 1264/06 (to SL), and a grant from Israel Cancer Association (to SL).

PY - 2011/8/1

Y1 - 2011/8/1

N2 - The human Septin 4 gene (Sept4) encodes two major protein isoforms; Sept4-i1 (H5/PNUTL2) and Sept4-i2/ARTS. Septins have been traditionally studied for their role in cytokinesis and their filament-forming abilities, but subsequently have been implicated in diverse functions, including membrane dynamics, cytoskeletal reorganization, vesicle trafficking, and tumorigenesis. ARTS is localized at mitochondria and promotes programmed cell death (apoptosis). These features distinguish ARTS from any other known human septin family member. This review compares the structural and functional properties of ARTS with other septins. In addition, it describes how a combination of two distinct promoters, differential splicing, and intron retention leads to the generation of two different Sept4 variants with diverse biological activity.

AB - The human Septin 4 gene (Sept4) encodes two major protein isoforms; Sept4-i1 (H5/PNUTL2) and Sept4-i2/ARTS. Septins have been traditionally studied for their role in cytokinesis and their filament-forming abilities, but subsequently have been implicated in diverse functions, including membrane dynamics, cytoskeletal reorganization, vesicle trafficking, and tumorigenesis. ARTS is localized at mitochondria and promotes programmed cell death (apoptosis). These features distinguish ARTS from any other known human septin family member. This review compares the structural and functional properties of ARTS with other septins. In addition, it describes how a combination of two distinct promoters, differential splicing, and intron retention leads to the generation of two different Sept4 variants with diverse biological activity.

KW - ARTS

KW - Sept4

KW - XIAP

KW - apoptosis

KW - mitochondria

KW - tumor suppressor protein

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U2 - 10.1515/BC.2011.089

DO - 10.1515/BC.2011.089

M3 - مقالة

C2 - 21824006

SN - 1431-6730

VL - 392

SP - 783

EP - 790

JO - Biological Chemistry

JF - Biological Chemistry

IS - 8-9

ER -

ARTS, the unusual septin: Structural and functional aspects

Abstract

UN SDGs

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

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