ARID5A promotes inflammation and fibrosis during cardiac aging: Cardiac aging

Shoval Miyara; Eldad Tzahor

doi:10.1038/s44161-025-00621-5

ARID5A promotes inflammation and fibrosis during cardiac aging: Cardiac aging

Shoval Miyara, Eldad Tzahor

Department of Molecular Cell Biology

Weizmann Institute of Science

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

A systematic biology approach identifies an RNA-binding protein, ARID5A, as a regulator of inflammation and fibrosis in the aging human heart. Inhibition of ARID5A reduced inflammation and fibrosis and improved cardiac function in old mice.

Original language	English
Journal	Nature Cardiovascular Research
DOIs	https://doi.org/10.1038/s44161-025-00621-5
State	Published - 29 Apr 2025

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology (miscellaneous)
Cell Biology
Medicine (miscellaneous)
Cardiology and Cardiovascular Medicine

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10.1038/s44161-025-00621-5

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title = "ARID5A promotes inflammation and fibrosis during cardiac aging: Cardiac aging",

abstract = "A systematic biology approach identifies an RNA-binding protein, ARID5A, as a regulator of inflammation and fibrosis in the aging human heart. Inhibition of ARID5A reduced inflammation and fibrosis and improved cardiac function in old mice.",

author = "Shoval Miyara and Eldad Tzahor",

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T1 - ARID5A promotes inflammation and fibrosis during cardiac aging

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AU - Miyara, Shoval

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AB - A systematic biology approach identifies an RNA-binding protein, ARID5A, as a regulator of inflammation and fibrosis in the aging human heart. Inhibition of ARID5A reduced inflammation and fibrosis and improved cardiac function in old mice.

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SN - 2731-0590

JO - Nature Cardiovascular Research

JF - Nature Cardiovascular Research

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ARID5A promotes inflammation and fibrosis during cardiac aging: Cardiac aging

Abstract

All Science Journal Classification (ASJC) codes

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