Applications of Atomic Force Microscopy in HIV-1 Research

Itay Rousso, Akshay Deshpande

Research output: Contribution to journalReview articlepeer-review


Obtaining an understanding of the mechanism underlying the interrelations between the structure and function of HIV-1 is of pivotal importance. In previous decades, this mechanism was addressed extensively in a variety of studies using conventional approaches. More recently, atomic force microscopy, which is a relatively new technique with unique capabilities, has been utilized to study HIV-1 biology. Atomic force microscopy can generate high-resolution images at the nanome-ter-scale and analyze the mechanical properties of individual HIV-1 virions, virus components (e.g., capsids), and infected live cells under near-physiological environments. This review describes the working principles and various imaging and analysis modes of atomic force microscopy, and elab-orates on its distinctive contributions to HIV-1 research in areas such as mechanobiology and the physics of infection.

Original languageAmerican English
Article number648
Issue number3
StatePublished - 1 Mar 2022


  • HIV-1
  • atomic force microscopy
  • imaging
  • mechanical properties

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Virology


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