Antiviral Activity of Peptide-Based Assemblies

Tan Hu, Omer Agazani, Sivan Nir, Mor Cohen, Siyi Pan, Meital Reches

Research output: Contribution to journalArticlepeer-review

Abstract

The COVID-19 pandemic highlighted the importance of developing surfaces and coatings with antiviral activity. Here, we present, for the first time, peptide-based assemblies that can kill viruses. The minimal inhibitory concentration (MIC) of the assemblies is in the range tens of micrograms per milliliter. This value is 2 orders of magnitude smaller than the MIC of metal nanoparticles. When applied on a surface, by drop casting, the peptide spherical assemblies adhere to the surface and form an antiviral coating against both RNA- and DNA-based viruses including coronavirus. Our results show that the coating reduced the number of T4 bacteriophages (DNA-based virus) by 3 log, compared with an untreated surface and 6 log, when compared with a stock solution. Importantly, we showed that this coating completely inactivated canine coronavirus (RNA-based virus). This peptide-based coating can be useful wherever sterile surfaces are needed to reduce the risk of viral transmission.

Original languageAmerican English
Pages (from-to)48469-48477
Number of pages9
JournalACS applied materials & interfaces
Volume13
Issue number41
DOIs
StatePublished - 20 Oct 2021

Keywords

  • antiviral coatings
  • bacteriophage T4
  • coronavirus
  • peptides
  • self-assembly

All Science Journal Classification (ASJC) codes

  • General Materials Science

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