ANTIBODIES WHICH BIND SOLUBLE T-CELL RECEPTOR LIGANDS

Yoram Reiter; Rony Dahan; Arthur A Vandenbark

ANTIBODIES WHICH BIND SOLUBLE T-CELL RECEPTOR LIGANDS

Yoram Reiter (Inventor), Rony Dahan (Inventor), Arthur A Vandenbark (Inventor)

Biology

Technion - Israel Institute of Technology

Research output: Patent

Abstract

Provided are isolated high affinity entities which comprise an antigen binding domain which specifically binds a soluble T-cell receptor ligand comprising a two-domain beta1-alpha1 of a major histocompatibility complex (MHC) class II, wherein said antigen binding domain does not bind a complex comprising a four-domain alpha1-beta1/alpha2-beta2 MHC class II. Also provided are methods and kits using same for detecting and sequestering soluble two-domain T cell receptor ligands in a sample.

Original language	American English
Patent number	US2014170168
IPC	G01N 33/ 564 A I
Priority date	26/10/11
State	Published - 19 Jun 2014

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title = "ANTIBODIES WHICH BIND SOLUBLE T-CELL RECEPTOR LIGANDS",

abstract = "Provided are isolated high affinity entities which comprise an antigen binding domain which specifically binds a soluble T-cell receptor ligand comprising a two-domain beta1-alpha1 of a major histocompatibility complex (MHC) class II, wherein said antigen binding domain does not bind a complex comprising a four-domain alpha1-beta1/alpha2-beta2 MHC class II. Also provided are methods and kits using same for detecting and sequestering soluble two-domain T cell receptor ligands in a sample.",

author = "Yoram Reiter and Rony Dahan and Vandenbark, {Arthur A}",

year = "2014",

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language = "American English",

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AU - Dahan, Rony

AU - Vandenbark, Arthur A

PY - 2014/6/19

Y1 - 2014/6/19

N2 - Provided are isolated high affinity entities which comprise an antigen binding domain which specifically binds a soluble T-cell receptor ligand comprising a two-domain beta1-alpha1 of a major histocompatibility complex (MHC) class II, wherein said antigen binding domain does not bind a complex comprising a four-domain alpha1-beta1/alpha2-beta2 MHC class II. Also provided are methods and kits using same for detecting and sequestering soluble two-domain T cell receptor ligands in a sample.

AB - Provided are isolated high affinity entities which comprise an antigen binding domain which specifically binds a soluble T-cell receptor ligand comprising a two-domain beta1-alpha1 of a major histocompatibility complex (MHC) class II, wherein said antigen binding domain does not bind a complex comprising a four-domain alpha1-beta1/alpha2-beta2 MHC class II. Also provided are methods and kits using same for detecting and sequestering soluble two-domain T cell receptor ligands in a sample.

M3 - Patent

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ER -

ANTIBODIES WHICH BIND SOLUBLE T-CELL RECEPTOR LIGANDS

Abstract

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