Antibiotic Resistance

Idan Yelin; Roy Kishony

doi:10.1016/j.cell.2018.02.018

Antibiotic Resistance

Idan Yelin
, Roy Kishony

Biology

Technion - Israel Institute of Technology

Research output: Contribution to journal › Short survey › peer-review

Abstract

Bacterial mechanisms of drug resistance operate at sequential lines of defense tackling drug at entry, accumulation, target binding, or downstream toxicity. These mechanisms are encoded by genomic changes ranging in scale from point mutations, through assembly of preexisting genetic elements, to horizontal import of genes from the environment. A many-to-many relationship prevails between resistance mechanisms and the spectrum of genetic changes encoding them. Bacterial mechanisms of drug resistance operate at sequential lines of defense tackling drug at entry, accumulation, target binding, or downstream toxicity. These mechanisms are encoded by genomic changes ranging in scale from point mutations, through assembly of preexisting genetic elements to horizontal import of genes from the environment. A many-to-many relationship prevails between resistance mechanisms and the spectrum of genetic changes encoding them.

Original language	English
Pages (from-to)	1136-1136.e1
Journal	Cell
Volume	172
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2018.02.018
State	Published - 22 Feb 2018

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

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10.1016/j.cell.2018.02.018

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title = "Antibiotic Resistance",

abstract = "Bacterial mechanisms of drug resistance operate at sequential lines of defense tackling drug at entry, accumulation, target binding, or downstream toxicity. These mechanisms are encoded by genomic changes ranging in scale from point mutations, through assembly of preexisting genetic elements, to horizontal import of genes from the environment. A many-to-many relationship prevails between resistance mechanisms and the spectrum of genetic changes encoding them. Bacterial mechanisms of drug resistance operate at sequential lines of defense tackling drug at entry, accumulation, target binding, or downstream toxicity. These mechanisms are encoded by genomic changes ranging in scale from point mutations, through assembly of preexisting genetic elements to horizontal import of genes from the environment. A many-to-many relationship prevails between resistance mechanisms and the spectrum of genetic changes encoding them.",

author = "Idan Yelin and Roy Kishony",

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AU - Yelin, Idan

AU - Kishony, Roy

PY - 2018/2/22

Y1 - 2018/2/22

N2 - Bacterial mechanisms of drug resistance operate at sequential lines of defense tackling drug at entry, accumulation, target binding, or downstream toxicity. These mechanisms are encoded by genomic changes ranging in scale from point mutations, through assembly of preexisting genetic elements, to horizontal import of genes from the environment. A many-to-many relationship prevails between resistance mechanisms and the spectrum of genetic changes encoding them. Bacterial mechanisms of drug resistance operate at sequential lines of defense tackling drug at entry, accumulation, target binding, or downstream toxicity. These mechanisms are encoded by genomic changes ranging in scale from point mutations, through assembly of preexisting genetic elements to horizontal import of genes from the environment. A many-to-many relationship prevails between resistance mechanisms and the spectrum of genetic changes encoding them.

AB - Bacterial mechanisms of drug resistance operate at sequential lines of defense tackling drug at entry, accumulation, target binding, or downstream toxicity. These mechanisms are encoded by genomic changes ranging in scale from point mutations, through assembly of preexisting genetic elements, to horizontal import of genes from the environment. A many-to-many relationship prevails between resistance mechanisms and the spectrum of genetic changes encoding them. Bacterial mechanisms of drug resistance operate at sequential lines of defense tackling drug at entry, accumulation, target binding, or downstream toxicity. These mechanisms are encoded by genomic changes ranging in scale from point mutations, through assembly of preexisting genetic elements to horizontal import of genes from the environment. A many-to-many relationship prevails between resistance mechanisms and the spectrum of genetic changes encoding them.

UR - https://www.scopus.com/pages/publications/85042359438

U2 - 10.1016/j.cell.2018.02.018

DO - 10.1016/j.cell.2018.02.018

M3 - Short survey

SN - 0092-8674

VL - 172

SP - 1136-1136.e1

JO - Cell

JF - Cell

IS - 5

ER -

Antibiotic Resistance

Abstract

ASJC Scopus subject areas

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