Anchoring of bacterial effectors to host membranes through host-mediated lipidation by prenylation: A common paradigm

Tasneem Al-Quadan, Christopher T. Price, Nir London, Ora Schueler-Furman, Yousef AbuKwaik

Research output: Contribution to journalComment/debate

Abstract

Post-translational lipidation by prenylation of the CaaX-box C-terminal motif in eukaryotic proteins facilitates anchoring of hydrophilic proteins, such as Ras and Rab, to membranes. A large cadre of bacterial effectors injected into host cells is anchored to host membranes by unknown mechanisms. As already documented for Legionella and Salmonella, we propose a common paradigm of microbial exploitation of the host prenylation machinery for anchoring of injected effectors to host membranes. This is supported by numerous potential microbial CaaX-box-containing proteins identified using refined bioinformatic tools. We also propose utilization of the CaaX motif as a membrane-targeting tag for proteins expressed in eukaryotic cells to facilitate deciphering of biological function.

Original languageAmerican English
Pages (from-to)573-579
Number of pages7
JournalTrends in Microbiology
Volume19
Issue number12
DOIs
StatePublished - Dec 2011

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Virology
  • Microbiology

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