Analyzing Amyloid Beta Aggregates with a Combinatorial Fluorescent Molecular Sensor

Joydev Hatai, Leila Motiei, David Margulies

Research output: Contribution to journalArticlepeer-review

Abstract

Different amyloid beta (A beta) aggregates can be discriminated by a combinatorial fluorescent molecular sensor. The unique optical fingerprints generated by the unimolecular analytical device provide a simple means to differentiate among aggregates generated from different alloforms or through distinct pathways. The sensor has also been used to track dynamic changes that occur in A beta aggregation states, which result from the formation of low molecular weight oligomers, high molecular weight oligomers, protofibrils, and fibrils.

Original languageEnglish
Pages (from-to)2136-2139
Number of pages4
JournalJournal of the American Chemical Society
Volume139
Issue number6
DOIs
StatePublished - 15 Feb 2017

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Biochemistry
  • Catalysis
  • Colloid and Surface Chemistry

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