Analysis of the genetic basis of height in large Jewish nuclear families

Danny Zeevi, Joshua S. Bloom, Meru J. Sadhu, Adi Ben Yehuda, David Zangen, Ephrat Levy-Lahad, Leonid Kruglyak

Research output: Contribution to journalArticlepeer-review


Despite intensive study, most of the specific genetic factors that contribute to variation in human height remain undiscovered. We conducted a family-based linkage study of height in a unique cohort of very large nuclear families from a founder (Jewish) population. This design allowed for increased power to detect linkage, compared to previous family-based studies. Loci we identified in discovery families could explain an estimated lower bound of 6% of the variance in height in validation families. We showed that these loci are not tagging known common variants associated with height. Rather, we suggest that the observed signals arise from variants with large effects that are rare globally but elevated in frequency in the Jewish population.

Original languageEnglish
Article numbere1008082
JournalPLoS Genetics
Issue number7
StatePublished - Jul 2019

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Genetics(clinical)
  • Cancer Research


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