Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma

XM Wei; A Moncada-Pazos; S Cal; C Soria-Valles; J Gartner; U Rudloff; JC Lin; SA Rosenberg; C Lopez-Otin; Yardena Samuels

doi:10.1002/humu.21477

Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma

XM Wei, A Moncada-Pazos, S Cal, C Soria-Valles, J Gartner, U Rudloff, JC Lin, SA Rosenberg, C Lopez-Otin, Yardena Samuels

Department of Molecular Cell Biology

Weizmann Institute of Science

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

We performed a mutational analysis of the 19 disintegrin-metalloproteinases (ADAMs) genes in human cutaneous metastatic melanoma and identified eight to be somatically mutated in 79 samples, affecting 34% of the melanoma tumors analyzed. Functional analysis of the two frequently mutated ADAM genes, ADAM29 and ADAM7 demonstrated that the mutations affect adhesion of melanoma cells to specific extracellular matrix proteins and in some cases increase their migration ability. This suggests that mutated ADAM genes could play a role in melanoma progression.

Original language	English
Pages (from-to)	E2148-E2175
Journal	Human Mutation
Volume	32
Issue number	6
DOIs	https://doi.org/10.1002/humu.21477
State	Published - Jun 2011

All Science Journal Classification (ASJC) codes

Genetics
Genetics(clinical)

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10.1002/humu.21477

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@article{2cc5f223ff124c87bfa5055c50ad068a,

title = "Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma",

abstract = "We performed a mutational analysis of the 19 disintegrin-metalloproteinases (ADAMs) genes in human cutaneous metastatic melanoma and identified eight to be somatically mutated in 79 samples, affecting 34% of the melanoma tumors analyzed. Functional analysis of the two frequently mutated ADAM genes, ADAM29 and ADAM7 demonstrated that the mutations affect adhesion of melanoma cells to specific extracellular matrix proteins and in some cases increase their migration ability. This suggests that mutated ADAM genes could play a role in melanoma progression.",

author = "XM Wei and A Moncada-Pazos and S Cal and C Soria-Valles and J Gartner and U Rudloff and JC Lin and SA Rosenberg and C Lopez-Otin and Yardena Samuels",

note = "National Human Genome Research Institute, National Institutes of Health; Ministerio de Ciencia e Innovacion-Spain; Fundacion {"}M. Botin{"}; European Union We thank Dr. R. Weinberg for the Mel-STR cell line and Dr. W. Gahl and W. Westbroek (National Institutes of Health) for normal melanocytes RNA. We thank T. Prickett and V. Walia for their helpful comments on the manuscript. We also thank members of the NISC Comparative Sequencing Program for providing leadership in the generation of the sequence data analyzed here. Funded by the National Human Genome Research Institute, National Institutes of Health to Y.S. and Ministerio de Ciencia e Innovacion-Spain, Fundacion {"}M. Botin{"}, and European Union (FP7 MicroEnviMet) to C.L-O.",

year = "2011",

month = jun,

doi = "10.1002/humu.21477",

language = "الإنجليزيّة",

volume = "32",

pages = "E2148--E2175",

journal = "Human Mutation",

issn = "1059-7794",

publisher = "John Wiley and Sons Inc.",

number = "6",

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TY - JOUR

T1 - Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma

AU - Wei, XM

AU - Moncada-Pazos, A

AU - Cal, S

AU - Soria-Valles, C

AU - Gartner, J

AU - Rudloff, U

AU - Lin, JC

AU - Rosenberg, SA

AU - Lopez-Otin, C

AU - Samuels, Yardena

N1 - National Human Genome Research Institute, National Institutes of Health; Ministerio de Ciencia e Innovacion-Spain; Fundacion "M. Botin"; European Union We thank Dr. R. Weinberg for the Mel-STR cell line and Dr. W. Gahl and W. Westbroek (National Institutes of Health) for normal melanocytes RNA. We thank T. Prickett and V. Walia for their helpful comments on the manuscript. We also thank members of the NISC Comparative Sequencing Program for providing leadership in the generation of the sequence data analyzed here. Funded by the National Human Genome Research Institute, National Institutes of Health to Y.S. and Ministerio de Ciencia e Innovacion-Spain, Fundacion "M. Botin", and European Union (FP7 MicroEnviMet) to C.L-O.

PY - 2011/6

Y1 - 2011/6

N2 - We performed a mutational analysis of the 19 disintegrin-metalloproteinases (ADAMs) genes in human cutaneous metastatic melanoma and identified eight to be somatically mutated in 79 samples, affecting 34% of the melanoma tumors analyzed. Functional analysis of the two frequently mutated ADAM genes, ADAM29 and ADAM7 demonstrated that the mutations affect adhesion of melanoma cells to specific extracellular matrix proteins and in some cases increase their migration ability. This suggests that mutated ADAM genes could play a role in melanoma progression.

AB - We performed a mutational analysis of the 19 disintegrin-metalloproteinases (ADAMs) genes in human cutaneous metastatic melanoma and identified eight to be somatically mutated in 79 samples, affecting 34% of the melanoma tumors analyzed. Functional analysis of the two frequently mutated ADAM genes, ADAM29 and ADAM7 demonstrated that the mutations affect adhesion of melanoma cells to specific extracellular matrix proteins and in some cases increase their migration ability. This suggests that mutated ADAM genes could play a role in melanoma progression.

UR - http://www.scopus.com/inward/record.url?scp=79957594872&partnerID=8YFLogxK

U2 - 10.1002/humu.21477

DO - 10.1002/humu.21477

M3 - تعليقَ / نقاش

SN - 1059-7794

VL - 32

SP - E2148-E2175

JO - Human Mutation

JF - Human Mutation

IS - 6

ER -

Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma

Abstract

All Science Journal Classification (ASJC) codes

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