Analysis of high-throughput microscopy videos: Catching up with cell dynamics

A. Arbelle, N. Drayman, M. Bray, U. Alon, A. Carpenter, T. Riklin Raviv

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We present a novel framework for high-throughput cell lineage analysis in time-lapse microscopy images. Our algorithm ties together two fundamental aspects of cell lineage construction, namely cell segmentation and tracking, via a Bayesian inference of dynamic models. The proposed contribution exploits the Kalman inference problem by estimating the time-wise cell shape uncertainty in addition to cell trajectory. These inferred cell properties are combined with the observed image measurements within a fast marching (FM) algorithm, to achieve posterior probabilities for cell segmentation and association. Highly accurate results on two different cell-tracking datasets are presented.

Original languageAmerican English
Title of host publicationMedical Image Computing and Computer-Assisted Intervention – MICCAI 2015 - 18th International Conference, Proceedings
Subtitle of host publication18th International Conference, Proceedings
EditorsAlejandro F. Frangi, Nassir Navab, Joachim Hornegger, William M. Wells
PublisherSpringer Verlag
Pages218-225
Number of pages8
ISBN (Print)9783319245737
DOIs
StatePublished - 1 Jan 2015
Event18th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2015 - Munich, Germany
Duration: 5 Oct 20159 Oct 2015

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9351

Conference

Conference18th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2015
Country/TerritoryGermany
CityMunich
Period5/10/159/10/15

All Science Journal Classification (ASJC) codes

  • Theoretical Computer Science
  • General Computer Science

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