An update on vaccines against Shigella

Shai Ashkenazi; Dani Cohen

doi:10.1177/2051013613500428

An update on vaccines against Shigella

Shai Ashkenazi, Dani Cohen

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

Despite intensive research efforts for more than 60 years, utilizing diverse vaccine strategies, a safe and efficacious vaccine against shigellosis is not available yet. We are currently witnessing innovative approaches based on elucidation of the virulence mechanisms of Shigella, understanding the immune response to the pathogen and progress in molecular technology for developing Shigella vaccines. It is hoped that these will lead to a licensed effective Shigella vaccine to protect humans against the significant worldwide morbidity and mortality caused by this microorganism.

Original language	English
Pages (from-to)	113-23
Number of pages	11
Journal	Therapeutic advances in vaccines
Volume	1
Issue number	3
DOIs	https://doi.org/10.1177/2051013613500428
State	Published - Sep 2013

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abstract = "Despite intensive research efforts for more than 60 years, utilizing diverse vaccine strategies, a safe and efficacious vaccine against shigellosis is not available yet. We are currently witnessing innovative approaches based on elucidation of the virulence mechanisms of Shigella, understanding the immune response to the pathogen and progress in molecular technology for developing Shigella vaccines. It is hoped that these will lead to a licensed effective Shigella vaccine to protect humans against the significant worldwide morbidity and mortality caused by this microorganism. ",

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AB - Despite intensive research efforts for more than 60 years, utilizing diverse vaccine strategies, a safe and efficacious vaccine against shigellosis is not available yet. We are currently witnessing innovative approaches based on elucidation of the virulence mechanisms of Shigella, understanding the immune response to the pathogen and progress in molecular technology for developing Shigella vaccines. It is hoped that these will lead to a licensed effective Shigella vaccine to protect humans against the significant worldwide morbidity and mortality caused by this microorganism.

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An update on vaccines against Shigella

Abstract

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