An inflammatory vicious cycle: Fibroblasts and immune cell recruitment in cancer

Yael Raz; Neta Erez

doi:10.1016/j.yexcr.2013.03.022

An inflammatory vicious cycle: Fibroblasts and immune cell recruitment in cancer

Yael Raz, Neta Erez

Pathology

Tel Aviv University

Research output: Contribution to journal › Review article › peer-review

Abstract

Cancer-associated fibroblasts (CAFs) have been established as a key component of the crosstalk between tumor cells and their microenvironment. The ability of CAFs to orchestrate tumor-promoting inflammation is central to their role in facilitating tumor growth, invasion, and metastasis. Here we review pathways by which CAFs and their soluble mediators provide multiple complex signals that modulate the recruitment, functional activation status, and retention of immune cells in the tumor microenvironment.

Original language	English
Pages (from-to)	1596-1603
Number of pages	8
Journal	Experimental Cell Research
Volume	319
Issue number	11
DOIs	https://doi.org/10.1016/j.yexcr.2013.03.022
State	Published - 1 Jul 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer
Cancer-associated fibroblasts
Inflammation
Microenvironment

All Science Journal Classification (ASJC) codes

Cell Biology

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10.1016/j.yexcr.2013.03.022

Cite this

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title = "An inflammatory vicious cycle: Fibroblasts and immune cell recruitment in cancer",

abstract = "Cancer-associated fibroblasts (CAFs) have been established as a key component of the crosstalk between tumor cells and their microenvironment. The ability of CAFs to orchestrate tumor-promoting inflammation is central to their role in facilitating tumor growth, invasion, and metastasis. Here we review pathways by which CAFs and their soluble mediators provide multiple complex signals that modulate the recruitment, functional activation status, and retention of immune cells in the tumor microenvironment.",

keywords = "Cancer, Cancer-associated fibroblasts, Inflammation, Microenvironment",

author = "Yael Raz and Neta Erez",

note = "Funding Information: We thank Dr. Ariel Munitz and Dr. Limor Landsman for critical reading of the manuscript, and Elad Yana for graphic design. NE acknowledges support from the European Union Seventh Framework Programme (FP7/2007–2013) under Grant agreement no. [ 276890 ], the Israel Cancer Association ( \#20110078 ), and from the Israel Cancer Research Fund (Research Career Development Award).",

year = "2013",

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doi = "10.1016/j.yexcr.2013.03.022",

language = "الإنجليزيّة",

volume = "319",

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TY - JOUR

T1 - An inflammatory vicious cycle

T2 - Fibroblasts and immune cell recruitment in cancer

AU - Raz, Yael

AU - Erez, Neta

N1 - Funding Information: We thank Dr. Ariel Munitz and Dr. Limor Landsman for critical reading of the manuscript, and Elad Yana for graphic design. NE acknowledges support from the European Union Seventh Framework Programme (FP7/2007–2013) under Grant agreement no. [ 276890 ], the Israel Cancer Association ( #20110078 ), and from the Israel Cancer Research Fund (Research Career Development Award).

PY - 2013/7/1

Y1 - 2013/7/1

N2 - Cancer-associated fibroblasts (CAFs) have been established as a key component of the crosstalk between tumor cells and their microenvironment. The ability of CAFs to orchestrate tumor-promoting inflammation is central to their role in facilitating tumor growth, invasion, and metastasis. Here we review pathways by which CAFs and their soluble mediators provide multiple complex signals that modulate the recruitment, functional activation status, and retention of immune cells in the tumor microenvironment.

AB - Cancer-associated fibroblasts (CAFs) have been established as a key component of the crosstalk between tumor cells and their microenvironment. The ability of CAFs to orchestrate tumor-promoting inflammation is central to their role in facilitating tumor growth, invasion, and metastasis. Here we review pathways by which CAFs and their soluble mediators provide multiple complex signals that modulate the recruitment, functional activation status, and retention of immune cells in the tumor microenvironment.

KW - Cancer

KW - Cancer-associated fibroblasts

KW - Inflammation

KW - Microenvironment

UR - http://www.scopus.com/inward/record.url?scp=84879607721&partnerID=8YFLogxK

U2 - 10.1016/j.yexcr.2013.03.022

DO - 10.1016/j.yexcr.2013.03.022

M3 - مقالة مرجعية

SN - 0014-4827

VL - 319

SP - 1596

EP - 1603

JO - Experimental Cell Research

JF - Experimental Cell Research

IS - 11

ER -

An inflammatory vicious cycle: Fibroblasts and immune cell recruitment in cancer

Abstract

UN SDGs

Keywords

All Science Journal Classification (ASJC) codes

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