Amylopectinosis of the fatal epilepsy Lafora disease resists autophagic glycogen catabolism

Jun Wu; Or Kakhlon; Miguel Weil; Alexander Lossos; Berge A. Minassian

doi:https://doi.org/10.1038/s44321-024-00063-9

Amylopectinosis of the fatal epilepsy Lafora disease resists autophagic glycogen catabolism

Jun Wu, Or Kakhlon, Miguel Weil, Alexander Lossos, Berge A. Minassian

Department of Cell Research and Immunology

Tel Aviv University

Research output: Contribution to journal › Letter › peer-review

Abstract

In this Correspondence, B. Minassian and colleagues report that GHF201, an autophagy activator shown to diminish abnormal glycogen aggregates in a mouse model of Adult Polyglucosan Body Disease, fails to reduce such accumulations in a mouse model of Lafora disease. (Figure presented.)

Original language	English
Pages (from-to)	1047-1050
Number of pages	4
Journal	EMBO Molecular Medicine
Volume	16
Issue number	5
DOIs	https://doi.org/10.1038/s44321-024-00063-9
State	Published - 16 May 2024

All Science Journal Classification (ASJC) codes

Molecular Medicine

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https://doi.org/10.1038/s44321-024-00063-9

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abstract = "In this Correspondence, B. Minassian and colleagues report that GHF201, an autophagy activator shown to diminish abnormal glycogen aggregates in a mouse model of Adult Polyglucosan Body Disease, fails to reduce such accumulations in a mouse model of Lafora disease. (Figure presented.)",

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AU - Wu, Jun

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AU - Minassian, Berge A.

PY - 2024/5/16

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N2 - In this Correspondence, B. Minassian and colleagues report that GHF201, an autophagy activator shown to diminish abnormal glycogen aggregates in a mouse model of Adult Polyglucosan Body Disease, fails to reduce such accumulations in a mouse model of Lafora disease. (Figure presented.)

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Amylopectinosis of the fatal epilepsy Lafora disease resists autophagic glycogen catabolism

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