Abstract
Despite extensive treatment, malignant brain tumors mostly recur due to the development of chemoresistance. Hereby, we attempt to sensitize residual tumor cells to chemotherapy using our established amphiphilic poly(α)glutamate:RNA interference polyplexes. Assembly via microfluidics resulted in defined, nanometric polyplexes, that internalized to brain tumor cells and induced specific gene silencing. These results paving the road for further antitumor therapy using RNA interference against chemoresistance mechanisms.
| Original language | English |
|---|---|
| Title of host publication | 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 |
| Pages | 1576-1577 |
| Number of pages | 2 |
| ISBN (Electronic) | 9781733419000 |
| State | Published - 2019 |
| Event | 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland Duration: 27 Oct 2019 → 31 Oct 2019 |
Publication series
| Name | 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 |
|---|
Conference
| Conference | 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 |
|---|---|
| Country/Territory | Switzerland |
| City | Basel |
| Period | 27/10/19 → 31/10/19 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Brain tumors
- Poly(α)glutamate (PGA)
- Polyplexes
- RNA interference (RNAi)
All Science Journal Classification (ASJC) codes
- Chemical Engineering (miscellaneous)
- Bioengineering
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