TY - GEN
T1 - Amphiphilic poly(α)glutamate as RNA interference nanocarrier to brain tumors
AU - Krivitsky, Adva
AU - Yeini, Eilam
AU - Pozzi, Sabina
AU - Golan, Sapir
AU - Pisarevsky, Evgeni
AU - Satchi-Fainaro, Ronit
N1 - Publisher Copyright: © 2019 CBMS-0001.
PY - 2019
Y1 - 2019
N2 - Despite extensive treatment, malignant brain tumors mostly recur due to the development of chemoresistance. Hereby, we attempt to sensitize residual tumor cells to chemotherapy using our established amphiphilic poly(α)glutamate:RNA interference polyplexes. Assembly via microfluidics resulted in defined, nanometric polyplexes, that internalized to brain tumor cells and induced specific gene silencing. These results paving the road for further antitumor therapy using RNA interference against chemoresistance mechanisms.
AB - Despite extensive treatment, malignant brain tumors mostly recur due to the development of chemoresistance. Hereby, we attempt to sensitize residual tumor cells to chemotherapy using our established amphiphilic poly(α)glutamate:RNA interference polyplexes. Assembly via microfluidics resulted in defined, nanometric polyplexes, that internalized to brain tumor cells and induced specific gene silencing. These results paving the road for further antitumor therapy using RNA interference against chemoresistance mechanisms.
KW - Brain tumors
KW - Poly(α)glutamate (PGA)
KW - Polyplexes
KW - RNA interference (RNAi)
UR - http://www.scopus.com/inward/record.url?scp=85094943528&partnerID=8YFLogxK
M3 - منشور من مؤتمر
T3 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
SP - 1576
EP - 1577
BT - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
T2 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Y2 - 27 October 2019 through 31 October 2019
ER -
