AMPA receptor neurotransmission and therapeutic applications: A comprehensive review of their multifaceted modulation

Mohammad Qneibi, Sosana Bdir, Mohammad Bdair, Samia Ammar Aldwaik, Dana Sandouka, Maram Heeh, Tala Iyad Idais

Research output: Contribution to journalReview articlepeer-review

Abstract

The neuropharmacological community has shown a strong interest in AMPA receptors as critical components of excitatory synaptic transmission during the last fifteen years. AMPA receptors, members of the ionotropic glutamate receptor family, allow rapid excitatory neurotransmission in the brain. AMPA receptors, which are permeable to sodium and potassium ions, manage the bulk of the brain's rapid synaptic communications. This study thoroughly examines the recent developments in AMPA receptor regulation, focusing on a shift from single chemical illustrations to a more extensive investigation of underlying processes. The complex interplay of these modulators in modifying the function and structure of AMPA receptors is the main focus, providing insight into their influence on the speed of excitatory neurotransmission. This research emphasizes the potential of AMPA receptor modulation as a therapy for various neurological disorders such as epilepsy and Alzheimer's disease. Analyzing these regulators' sophisticated molecular details enhances our comprehension of neuropharmacology, representing a significant advancement in using AMPA receptors for treating intricate neurological conditions.

Original languageAmerican English
Article number116151
JournalEuropean Journal of Medicinal Chemistry
Volume266
DOIs
StatePublished - 15 Feb 2024
Externally publishedYes

Keywords

  • AMPA receptor
  • Alzheimer's disease
  • Epilepsy
  • Negative allosteric modulators
  • Positive allosteric modulators

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Pharmacology
  • Organic Chemistry

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