Alzheimer's Disease and Mechanism-Based Attempts to Enhance Cognition

Jonathan E. Draffin, Shira Knafo, Michael T. Heneka

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Alzheimer's disease (AD) is the leading neurodegenerative disease worldwide and the expected rise in patient numbers is a critical threat to our health care systems. Current treatment strategies are of limited efficacy and only transiently active. Thus, there is an urgent need for a better understanding of the pathomechanisms involved, the precise sequence of events, and potential drug targets. Current research strategies are based on studies on animal models of the disease and mostly focus on interference with the key pathological hallmarks, beta-amyloid peptide accumulation and deposition and the neurofibrillary tangle formation. Further efforts need to be invested to complement our knowledge about AD and to identify new times and sites of therapeutic intervention.

Original languageAmerican English
Title of host publicationCognitive Enhancement
Subtitle of host publicationPharmacologic, Environmental and Genetic Factors
Number of pages39
ISBN (Electronic)9780124171251
ISBN (Print)9780124170421
StatePublished - 8 Jan 2015
Externally publishedYes


  • Amyloid precursor protein
  • Amyloid-beta
  • Cognitive impairment
  • Synapse
  • Transgenic mice

All Science Journal Classification (ASJC) codes

  • General Medicine


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