TY - JOUR
T1 - alpha-Sila-Dipeptides: Synthesis and Characterization
T2 - Synthesis and Characterization
AU - Minkovich, Boris
AU - Ruderfer, Ilya
AU - Kaushansky, Alexander
AU - Bravo-Zhivotovskii, Dmitry
AU - Apeloig, Yitzhak
N1 - Publisher Copyright: © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2018/10/1
Y1 - 2018/10/1
N2 - The first two α-sila-dipeptides, 7 and cyclo-sila-dipeptide 8, were synthesized and characterized by several methods, including X-ray crystallography. Bulky t-BuMe2Si substituents provide some kinetic stabilization to the synthesized molecules. 7 and 8 are the first examples of a “Si for C switch” in the central α-position of an amino acid or a peptide, in which silicon is bonded to both the amino and the carbonyl groups.
AB - The first two α-sila-dipeptides, 7 and cyclo-sila-dipeptide 8, were synthesized and characterized by several methods, including X-ray crystallography. Bulky t-BuMe2Si substituents provide some kinetic stabilization to the synthesized molecules. 7 and 8 are the first examples of a “Si for C switch” in the central α-position of an amino acid or a peptide, in which silicon is bonded to both the amino and the carbonyl groups.
KW - Si for C switch
KW - alpha-sila-dipeptides
KW - peptidomimetics
KW - sila-piperazine
UR - http://www.scopus.com/inward/record.url?scp=85053410056&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/anie.201807027
DO - https://doi.org/10.1002/anie.201807027
M3 - مقالة
SN - 1433-7851
VL - 57
SP - 13261
EP - 13265
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 40
ER -