alpha-Sila-Dipeptides: Synthesis and Characterization: Synthesis and Characterization

Boris Minkovich, Ilya Ruderfer, Alexander Kaushansky, Dmitry Bravo-Zhivotovskii, Yitzhak Apeloig

Research output: Contribution to journalArticlepeer-review

Abstract

The first two α-sila-dipeptides, 7 and cyclo-sila-dipeptide 8, were synthesized and characterized by several methods, including X-ray crystallography. Bulky t-BuMe2Si substituents provide some kinetic stabilization to the synthesized molecules. 7 and 8 are the first examples of a “Si for C switch” in the central α-position of an amino acid or a peptide, in which silicon is bonded to both the amino and the carbonyl groups.

Original languageEnglish
Pages (from-to)13261-13265
Number of pages5
JournalAngewandte Chemie - International Edition
Volume57
Issue number40
DOIs
StatePublished - 1 Oct 2018

Keywords

  • Si for C switch
  • alpha-sila-dipeptides
  • peptidomimetics
  • sila-piperazine

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Catalysis

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