TY - JOUR
T1 - Age-related new bone formation following the use of cancellous bone-block allografts for reconstruction of atrophic alveolar ridges
AU - Nissan, Joseph
AU - Kolerman, Roni
AU - Chaushu, Liat
AU - Vered, Marilena
AU - Naishlos, Sarit
AU - Chaushu, Gavriel
N1 - Publisher Copyright: © 2017 Wiley Periodicals, Inc.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Background: An age-related decrease in the number of osteogenic progenitor cells may compromise bone augmentation. Purpose: Histomorphometrical assessment of age-related new bone formation, following atrophic alveolar ridge reconstruction, using cancellous bone-block allografts. Material and methods: Ninety-three consecutive patients (58 females and 35 males) were referred for implant-supported restoration of 122 severe atrophic alveolar ridges. Alveolar ridge deficiency locations were classified as anterior maxilla (n = 58), posterior maxilla (n= 32), and posterior mandible (n = 32). A bony deficiency of at least 3 mm horizontally and up to 3 mm vertically according to computerized tomography (CT) in the posterior mandible and anterior maxilla, served as inclusion criteria. In the posterior maxilla, a residual alveolar ridge up to 4 mm vertically according to CT served as inclusion criteria. Augmentation was performed by the use of cancellous bone-block allografts. Bone biopsies (9-month posterior maxilla, 4 months anterior maxilla and posterior mandible) of young (≤40 years) versus older (>40 years) patients were histomorphometrically evaluated. Results: In the posterior maxilla, no statistically significant histomorphometric differences were noted. While at the anterior maxilla and posterior mandible, statistically significant more newly formed bone was found in young versus older individuals, respectively (38.6% vs 19.8%, P = 0.04 and 69% vs 31%, P =.05). Conclusion: New bone formation following residual alveolar ridge bone grafting is age-related. Longer bone consolidation and healing time may be recommended for older individuals.
AB - Background: An age-related decrease in the number of osteogenic progenitor cells may compromise bone augmentation. Purpose: Histomorphometrical assessment of age-related new bone formation, following atrophic alveolar ridge reconstruction, using cancellous bone-block allografts. Material and methods: Ninety-three consecutive patients (58 females and 35 males) were referred for implant-supported restoration of 122 severe atrophic alveolar ridges. Alveolar ridge deficiency locations were classified as anterior maxilla (n = 58), posterior maxilla (n= 32), and posterior mandible (n = 32). A bony deficiency of at least 3 mm horizontally and up to 3 mm vertically according to computerized tomography (CT) in the posterior mandible and anterior maxilla, served as inclusion criteria. In the posterior maxilla, a residual alveolar ridge up to 4 mm vertically according to CT served as inclusion criteria. Augmentation was performed by the use of cancellous bone-block allografts. Bone biopsies (9-month posterior maxilla, 4 months anterior maxilla and posterior mandible) of young (≤40 years) versus older (>40 years) patients were histomorphometrically evaluated. Results: In the posterior maxilla, no statistically significant histomorphometric differences were noted. While at the anterior maxilla and posterior mandible, statistically significant more newly formed bone was found in young versus older individuals, respectively (38.6% vs 19.8%, P = 0.04 and 69% vs 31%, P =.05). Conclusion: New bone formation following residual alveolar ridge bone grafting is age-related. Longer bone consolidation and healing time may be recommended for older individuals.
KW - alveolar ridge bone allograft
KW - bone formation
KW - histological analysis
KW - reconstruction
UR - http://www.scopus.com/inward/record.url?scp=85036515839&partnerID=8YFLogxK
U2 - https://doi.org/10.1111/cid.12560
DO - https://doi.org/10.1111/cid.12560
M3 - مقالة
SN - 1523-0899
VL - 20
SP - 4
EP - 8
JO - Clinical Implant Dentistry and Related Research
JF - Clinical Implant Dentistry and Related Research
IS - 1
ER -