TY - JOUR
T1 - Age-related changes of myocardial ATP supply and demand mechanisms
AU - Yaniv, Yael
AU - Juhaszova, Magdalena
AU - Sollott, Steven J.
N1 - Funding Information: We thank Dr Edward G. Lakatta for useful discussions. This work was supported entirely by the Intramural Research Program of the National Institute on Aging, National Institutes of Health.
PY - 2013/10
Y1 - 2013/10
N2 - In advanced age, the resting myocardial oxygen consumption rate (MVO2) and cardiac work (CW) in the rat remain intact. However, MVO2, CW and cardiac efficiency achieved at high demand are decreased with age, compared to maximal values in the young. Whether this deterioration is due to decrease in myocardial ATP demand, ATP supply, or the control mechanisms that match them remains controversial. Here we discuss evolving perspectives of age-related changes of myocardial ATP supply and demand mechanisms, and critique experimental models used to investigate aging. Specifically, we evaluate experimental data collected at the level of isolated mitochondria, tissue, or organism, and discuss how mitochondrial energetic mechanisms change in advanced age, both at basal and high energy-demand levels.
AB - In advanced age, the resting myocardial oxygen consumption rate (MVO2) and cardiac work (CW) in the rat remain intact. However, MVO2, CW and cardiac efficiency achieved at high demand are decreased with age, compared to maximal values in the young. Whether this deterioration is due to decrease in myocardial ATP demand, ATP supply, or the control mechanisms that match them remains controversial. Here we discuss evolving perspectives of age-related changes of myocardial ATP supply and demand mechanisms, and critique experimental models used to investigate aging. Specifically, we evaluate experimental data collected at the level of isolated mitochondria, tissue, or organism, and discuss how mitochondrial energetic mechanisms change in advanced age, both at basal and high energy-demand levels.
KW - Aging
KW - Bioenergetics
KW - Cardiac work
KW - Mitochondria
KW - Respiration
UR - http://www.scopus.com/inward/record.url?scp=84884415229&partnerID=8YFLogxK
U2 - 10.1016/j.tem.2013.06.001
DO - 10.1016/j.tem.2013.06.001
M3 - مقالة مرجعية
SN - 1043-2760
VL - 24
SP - 495
EP - 505
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 10
ER -