Age of onset in obsessive-compulsive disorder: Admixture analysis with a large sample

G. E. Anholt, I. M. Aderka, A. J.L.M. Van Balkom, J. H. Smit, K. Schruers, N. J.A. Van Der Wee, M. Eikelenboom, V. De Luca, P. Van Oppen

Research output: Contribution to journalArticlepeer-review


Background Research into age of onset in obsessive-compulsive disorder (OCD) has indicated significant differences between patients with early and late onset of the disorder. However, multiple criteria have been used arbitrarily for differentiating between early-and late-onset OCD, rendering inconsistent results that are difficult to interpret. Method In the current study, admixture analysis was conducted in a sample of 377 OC patients to determine the number of underlying populations of age of onset and associated demographic and clinical characteristics. Various measures of anxiety, depression, co-morbidity, autism, OCD, tics and attention deficit hyperactivity disorder (ADHD) symptoms were administered. Results A bimodal age of onset was established and the best-fitting cut-off score between early and late age of onset was 20 years (early age of onset â

Original languageEnglish
Pages (from-to)185-194
Number of pages10
JournalPsychological Medicine
Issue number1
StatePublished - 1 Jan 2014


  • Admixture analysis
  • age of onset
  • obsessive-compulsive disorder

All Science Journal Classification (ASJC) codes

  • Applied Psychology
  • Psychiatry and Mental health


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