TY - JOUR
T1 - Age-Dependent Trends in the Celiac Disease
T2 - A Tertiary Center Experience
AU - Krauthammer, Alexander
AU - Guz-Mark, Anat
AU - Zevit, Noam
AU - Marderfeld, Luba
AU - Waisbourd-Zinman, Orith
AU - Silbermintz, Ari
AU - Mozer-Glassberg, Yael
AU - Nachmias Friedler, Vered
AU - Rozenfeld Bar Lev, Michal
AU - Matar, Manar
AU - Assa, Amit
AU - Shamir, Raanan
N1 - Publisher Copyright: Copyright © 2021 ESPGHAN and NASPGHAN. All rights reserved.
PY - 2021/6/1
Y1 - 2021/6/1
N2 - Objectives: Celiac disease (CD) is a common intestinal autoimmune disorder with diverse presenting features. We aimed to determine age-dependent patterns in CD presentation, diagnosis and management at a large tertiary referral center. Methods: A retrospective review of electronic medical records of pediatric patients diagnosed with CD between January 1999 and December 2018 at Schneider Children's Medical Center of Israel. We compared demographics, clinical and laboratory parameters between four age groups at CD presentation. Results: A cohort of 932 children was divided into four groups by age (in years) at diagnosis: 0-3 (17.9%), 3-6 (31.8%), 6-12 (34.5%), 12-18 (15.8%). The youngest age group presented more frequently with diarrhea, weight loss, abdominal distention, vomiting and lower weight z scores, P < 0.01. Hypoalbuminemia and zinc deficiency were also more frequent in this age group, compared to older patients (P < 0.05, each). Rates of anemia were higher in younger age groups (0-3 and 3-6 years), compared to older age groups, P < 0.05. Patients in the younger age groups (0-3 and 3-6 years) presented more frequently with tissue transglutaminase (TTG) levels above 10 times the upper limit of normal (ULN; P < 0.05), and more often normalized their CD serologies by 24 months of gluten-free diets (GFD) compared to older age groups (P < 0.05). Conclusion: There is an age-dependent variation in CD presentation during childhood. Younger patients present more often with malabsorptive features, and higher TTG levels, yet normalize TTG while on GFD more rapidly than older patients. Clinicians should be aware of the diversity in CD presentation and course at the various presentation age.
AB - Objectives: Celiac disease (CD) is a common intestinal autoimmune disorder with diverse presenting features. We aimed to determine age-dependent patterns in CD presentation, diagnosis and management at a large tertiary referral center. Methods: A retrospective review of electronic medical records of pediatric patients diagnosed with CD between January 1999 and December 2018 at Schneider Children's Medical Center of Israel. We compared demographics, clinical and laboratory parameters between four age groups at CD presentation. Results: A cohort of 932 children was divided into four groups by age (in years) at diagnosis: 0-3 (17.9%), 3-6 (31.8%), 6-12 (34.5%), 12-18 (15.8%). The youngest age group presented more frequently with diarrhea, weight loss, abdominal distention, vomiting and lower weight z scores, P < 0.01. Hypoalbuminemia and zinc deficiency were also more frequent in this age group, compared to older patients (P < 0.05, each). Rates of anemia were higher in younger age groups (0-3 and 3-6 years), compared to older age groups, P < 0.05. Patients in the younger age groups (0-3 and 3-6 years) presented more frequently with tissue transglutaminase (TTG) levels above 10 times the upper limit of normal (ULN; P < 0.05), and more often normalized their CD serologies by 24 months of gluten-free diets (GFD) compared to older age groups (P < 0.05). Conclusion: There is an age-dependent variation in CD presentation during childhood. Younger patients present more often with malabsorptive features, and higher TTG levels, yet normalize TTG while on GFD more rapidly than older patients. Clinicians should be aware of the diversity in CD presentation and course at the various presentation age.
KW - Aged
KW - Autoantibodies
KW - Celiac Disease/diagnosis
KW - Child
KW - Diet, Gluten-Free
KW - Humans
KW - Israel/epidemiology
KW - Retrospective Studies
KW - Transglutaminases
KW - celiac
KW - children
KW - follow up
KW - presentation
KW - serology
KW - tissue transglutaminase
UR - http://www.scopus.com/inward/record.url?scp=85106540734&partnerID=8YFLogxK
U2 - https://doi.org/10.1097/MPG.0000000000003130
DO - https://doi.org/10.1097/MPG.0000000000003130
M3 - مقالة
C2 - 33908739
SN - 0277-2116
VL - 72
SP - 894
EP - 899
JO - Journal of Pediatric Gastroenterology and Nutrition
JF - Journal of Pediatric Gastroenterology and Nutrition
IS - 6
ER -