TY - JOUR
T1 - Advances in vascularization and innervation of constructs for neural tissue engineering
AU - Newman Frisch, Abigail
AU - Debbi, Lior
AU - Shuhmaher, Margarita
AU - Guo, Shaowei
AU - Levenberg, Shulamit
N1 - Publisher Copyright: © 2021 Elsevier Ltd
PY - 2022/2
Y1 - 2022/2
N2 - A growing number of technologies are being developed to promote vascularization and innervation in engineered tissues. Organ-on-a-chip, organoid and 3D printing technologies, as well as pre-vascularized and oriented scaffolds, have been employed for vascularization and innervation of engineered tissues both in vivo and in vitro. Both vascularization and innervation are critical for neural tissue engineering, as these complex tissues require provision of both blood and nerves. As such, this review will have particular focus on neural tissue engineering. We examine state-of-the-art approaches for tissue vascularization and innervation and identify promising methods for developing vascularized and innervated engineered neural constructs.
AB - A growing number of technologies are being developed to promote vascularization and innervation in engineered tissues. Organ-on-a-chip, organoid and 3D printing technologies, as well as pre-vascularized and oriented scaffolds, have been employed for vascularization and innervation of engineered tissues both in vivo and in vitro. Both vascularization and innervation are critical for neural tissue engineering, as these complex tissues require provision of both blood and nerves. As such, this review will have particular focus on neural tissue engineering. We examine state-of-the-art approaches for tissue vascularization and innervation and identify promising methods for developing vascularized and innervated engineered neural constructs.
UR - http://www.scopus.com/inward/record.url?scp=85113913792&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.copbio.2021.08.012
DO - https://doi.org/10.1016/j.copbio.2021.08.012
M3 - مقالة مرجعية
SN - 0958-1669
VL - 73
SP - 188
EP - 197
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
ER -