Adoptive T-cell immunotherapy: Perfecting self-defenses

Katrina Shamalov, Yair Tal, Chen Ankri, Cyrille J. Cohen

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The unrivaled potential of T cells for targeted immune function is central to the eradication of cancer. While their natural anti-tumor response might sometimes be insufficient, several studies and importantly, multiple clinical trials in terminally-ill cancer patients have demonstrated that it is possible to design novel and efficient immunotherapeutic approaches based on the adoptive transfer of autologous tumor-specific T lymphocytes. Herein, we will expand on the development and the use of such strategies using tumor-infiltrating lymphocytes or genetically-engineered T cells. We will also comment on the requirements and potential hurdles encountered when elaborating and implementing such treatments as well as the exciting prospects for this kind of emerging personalized medicine therapy.

Original languageEnglish
Title of host publicationInteraction of Immune and Cancer Cells
PublisherSpringer-Verlag Wien
Pages207-232
Number of pages26
ISBN (Electronic)9783709113004
ISBN (Print)3709112990, 9783709112991
DOIs
StatePublished - 1 Jan 2014

All Science Journal Classification (ASJC) codes

  • General Immunology and Microbiology
  • General Medicine

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