Adaptive response and enlargement of dynamic range

Research output: Contribution to journalArticlepeer-review


Many membrane channels and receptors exhibit adaptive, or desensitized, response to a strong sustained input stimulus, often supported by protein activity-dependent inactivation. Adaptive response is thought to be related to various cellular functions such as homeostasis and enlargement of dynamic range by background compensation. Here we study the quantitative relation between adaptive response and background compensation within a modeling framework. We show that any particular type of adaptive response is neither sufficient nor necessary for adaptive enlargement of dynamic range. In particular a precise adaptive response, where system activity is maintained at a constant level at steady state, does not ensure a large dynamic range neither in input signal nor in system output. A general mechanism for input dynamic range enlargement can come about from the activity-dependent modulation of protein responsiveness by multiple biochemical modification, regardless of the type of adaptive response it induces. Therefore hierarchical biochemical processes such as methylation and phosphorylation are natural candidates to induce this property in signaling systems.

Original languageAmerican English
Pages (from-to)515-526
Number of pages12
JournalMathematical Biosciences and Engineering
Issue number2
StatePublished - Apr 2011


  • Adaptive response
  • Biological networks
  • Dynamic range
  • Feedback
  • Integral control
  • Signal processing

All Science Journal Classification (ASJC) codes

  • Computational Mathematics
  • Applied Mathematics
  • General Agricultural and Biological Sciences
  • Modelling and Simulation


Dive into the research topics of 'Adaptive response and enlargement of dynamic range'. Together they form a unique fingerprint.

Cite this