Acute oral cannabidiolic acid methyl ester reduces depression-like behavior in two genetic animal models of depression

D. Hen-Shoval; S. Amar; L. Shbiro; R. Smoum; Christeene G. Haj; R. Mechoulam; G. Zalsman; A. Weller; G. Shoval

doi:10.1016/j.bbr.2018.05.027

Acute oral cannabidiolic acid methyl ester reduces depression-like behavior in two genetic animal models of depression

D. Hen-Shoval, S. Amar, L. Shbiro, R. Smoum, Christeene G. Haj, R. Mechoulam, G. Zalsman, A. Weller, G. Shoval

Tel Aviv University, Bar-Ilan University, The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

Background and purpose: Cannabidiolic acid methyl ester (HU-580) was recently shown to reduce stress-induced anxiety-like behavior in rats. The aim of this study was to examine the antidepressant effect of HU-580 in two different rat models of depression. Experimental approach: Using the forced swim test (FST), we evaluated the effect of HU-580 in 43 Wistar–Kyoto (WKY) and 23 Flinders Sensitive Line (FSL) adult male rats. Key results: 1 mg/kg HU-580 reduced immobility and increased swimming in WKY rats, compared to vehicle-treated controls (p < 0.05). This dose exerted similar effects in FSL rats (p < 0.05). Conclusion and implications: This is the first report of antidepressant efficacy of HU-580. These findings expand the very limited existent results, suggesting that HU-580 is a potent anxiolytic agent. Taken together with its chemical stability, HU-580 emerges as a candidate for a future antidepressant medication.

Original language	English
Pages (from-to)	1-3
Number of pages	3
Journal	Behavioural Brain Research
Volume	351
DOIs	https://doi.org/10.1016/j.bbr.2018.05.027
State	Published - 1 Oct 2018

Keywords

Cannabidiolic acid methyl ester
Flinders Sensitive Line (FSL)
Forced swim test (FST)
Genetic animal models of depression
Major depression disorder (MDD)
Wistar–Kyoto (WKY)

All Science Journal Classification (ASJC) codes

Behavioral Neuroscience

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10.1016/j.bbr.2018.05.027

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title = "Acute oral cannabidiolic acid methyl ester reduces depression-like behavior in two genetic animal models of depression",

abstract = "Background and purpose: Cannabidiolic acid methyl ester (HU-580) was recently shown to reduce stress-induced anxiety-like behavior in rats. The aim of this study was to examine the antidepressant effect of HU-580 in two different rat models of depression. Experimental approach: Using the forced swim test (FST), we evaluated the effect of HU-580 in 43 Wistar–Kyoto (WKY) and 23 Flinders Sensitive Line (FSL) adult male rats. Key results: 1 mg/kg HU-580 reduced immobility and increased swimming in WKY rats, compared to vehicle-treated controls (p < 0.05). This dose exerted similar effects in FSL rats (p < 0.05). Conclusion and implications: This is the first report of antidepressant efficacy of HU-580. These findings expand the very limited existent results, suggesting that HU-580 is a potent anxiolytic agent. Taken together with its chemical stability, HU-580 emerges as a candidate for a future antidepressant medication.",

keywords = "Cannabidiolic acid methyl ester, Flinders Sensitive Line (FSL), Forced swim test (FST), Genetic animal models of depression, Major depression disorder (MDD), Wistar–Kyoto (WKY)",

author = "D. Hen-Shoval and S. Amar and L. Shbiro and R. Smoum and Haj, {Christeene G.} and R. Mechoulam and G. Zalsman and A. Weller and G. Shoval",

note = "Publisher Copyright: {\textcopyright} 2018",

year = "2018",

month = oct,

day = "1",

doi = "10.1016/j.bbr.2018.05.027",

language = "الإنجليزيّة",

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T1 - Acute oral cannabidiolic acid methyl ester reduces depression-like behavior in two genetic animal models of depression

AU - Hen-Shoval, D.

AU - Amar, S.

AU - Shbiro, L.

AU - Smoum, R.

AU - Haj, Christeene G.

AU - Mechoulam, R.

AU - Zalsman, G.

AU - Weller, A.

AU - Shoval, G.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Background and purpose: Cannabidiolic acid methyl ester (HU-580) was recently shown to reduce stress-induced anxiety-like behavior in rats. The aim of this study was to examine the antidepressant effect of HU-580 in two different rat models of depression. Experimental approach: Using the forced swim test (FST), we evaluated the effect of HU-580 in 43 Wistar–Kyoto (WKY) and 23 Flinders Sensitive Line (FSL) adult male rats. Key results: 1 mg/kg HU-580 reduced immobility and increased swimming in WKY rats, compared to vehicle-treated controls (p < 0.05). This dose exerted similar effects in FSL rats (p < 0.05). Conclusion and implications: This is the first report of antidepressant efficacy of HU-580. These findings expand the very limited existent results, suggesting that HU-580 is a potent anxiolytic agent. Taken together with its chemical stability, HU-580 emerges as a candidate for a future antidepressant medication.

AB - Background and purpose: Cannabidiolic acid methyl ester (HU-580) was recently shown to reduce stress-induced anxiety-like behavior in rats. The aim of this study was to examine the antidepressant effect of HU-580 in two different rat models of depression. Experimental approach: Using the forced swim test (FST), we evaluated the effect of HU-580 in 43 Wistar–Kyoto (WKY) and 23 Flinders Sensitive Line (FSL) adult male rats. Key results: 1 mg/kg HU-580 reduced immobility and increased swimming in WKY rats, compared to vehicle-treated controls (p < 0.05). This dose exerted similar effects in FSL rats (p < 0.05). Conclusion and implications: This is the first report of antidepressant efficacy of HU-580. These findings expand the very limited existent results, suggesting that HU-580 is a potent anxiolytic agent. Taken together with its chemical stability, HU-580 emerges as a candidate for a future antidepressant medication.

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KW - Flinders Sensitive Line (FSL)

KW - Forced swim test (FST)

KW - Genetic animal models of depression

KW - Major depression disorder (MDD)

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U2 - 10.1016/j.bbr.2018.05.027

DO - 10.1016/j.bbr.2018.05.027

M3 - مقالة

C2 - 29860002

SN - 0166-4328

VL - 351

SP - 1

EP - 3

JO - Behavioural Brain Research

JF - Behavioural Brain Research

ER -

Acute oral cannabidiolic acid methyl ester reduces depression-like behavior in two genetic animal models of depression

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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