Activity-driven fluctuations in living cells

E. Fodor, M. Guo, Nir Gov, P. Visco, D. A. Weitz, F. van Wijland

Research output: Contribution to journalArticlepeer-review


We propose a model for the dynamics of a probe embedded in a living cell, where both thermal fluctuations and nonequilibrium activity coexist. The model is based on a confining harmonic potential describing the elastic cytoskeletal matrix, which undergoes random active hops as a result of the nonequilibrium rearrangements within the cell. We describe the probe's statistics and we bring forth quantities affected by the nonequilibrium activity. We find an excellent agreement between the predictions of our model and experimental results for tracers inside living cells. Finally, we exploit our model to arrive at quantitative predictions for the parameters characterizing nonequilibrium activity, such as the typical time scale of the activity and the amplitude of the active fluctuations. Copyright (C) EPLA, 2015
Original languageEnglish
Article number48005
Number of pages6
Issue number4
StatePublished - May 2015


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