Activation of Oncogenic Super-Enhancers Is Coupled with DNA Repair by RAD51

Idit Hazan; Jonathan Monin; Britta A.M. Bouwman; Nicola Crosetto; Rami I. Aqeilan

doi:https://doi.org/10.1016/j.celrep.2019.09.001

Activation of Oncogenic Super-Enhancers Is Coupled with DNA Repair by RAD51

Idit Hazan, Jonathan Monin, Britta A.M. Bouwman, Nicola Crosetto, Rami I. Aqeilan

Department of Immunology and Cancer Research

The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

By mapping physiological double-strand breaks (DSBs) of tumorigenic and non-tumorigenic cells Hazan et al. uncover a coupled transcription-repair mechanism at oncogenic super-enhancers in which RAD51 of the homologous recombination pathway plays a key role supporting the hyper-transcription of related oncogenes.

Original language	English
Pages (from-to)	560-572.e4
Journal	Cell Reports
Volume	29
Issue number	3
DOIs	https://doi.org/10.1016/j.celrep.2019.09.001
State	Published - 15 Oct 2019

Keywords

AP-1 complex (JUN/FOS)
BLISS
DSBs
RAD51
TEAD4
super-enhancer
transcription

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://doi.org/10.1016/j.celrep.2019.09.001

Cite this

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title = "Activation of Oncogenic Super-Enhancers Is Coupled with DNA Repair by RAD51",

abstract = "By mapping physiological double-strand breaks (DSBs) of tumorigenic and non-tumorigenic cells Hazan et al. uncover a coupled transcription-repair mechanism at oncogenic super-enhancers in which RAD51 of the homologous recombination pathway plays a key role supporting the hyper-transcription of related oncogenes.",

keywords = "AP-1 complex (JUN/FOS), BLISS, DSBs, RAD51, TEAD4, super-enhancer, transcription",

author = "Idit Hazan and Jonathan Monin and Bouwman, {Britta A.M.} and Nicola Crosetto and Aqeilan, {Rami I.}",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s)",

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day = "15",

doi = "https://doi.org/10.1016/j.celrep.2019.09.001",

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T1 - Activation of Oncogenic Super-Enhancers Is Coupled with DNA Repair by RAD51

AU - Hazan, Idit

AU - Monin, Jonathan

AU - Bouwman, Britta A.M.

AU - Crosetto, Nicola

AU - Aqeilan, Rami I.

PY - 2019/10/15

Y1 - 2019/10/15

N2 - By mapping physiological double-strand breaks (DSBs) of tumorigenic and non-tumorigenic cells Hazan et al. uncover a coupled transcription-repair mechanism at oncogenic super-enhancers in which RAD51 of the homologous recombination pathway plays a key role supporting the hyper-transcription of related oncogenes.

AB - By mapping physiological double-strand breaks (DSBs) of tumorigenic and non-tumorigenic cells Hazan et al. uncover a coupled transcription-repair mechanism at oncogenic super-enhancers in which RAD51 of the homologous recombination pathway plays a key role supporting the hyper-transcription of related oncogenes.

KW - AP-1 complex (JUN/FOS)

KW - BLISS

KW - DSBs

KW - RAD51

KW - TEAD4

KW - super-enhancer

KW - transcription

UR - http://www.scopus.com/inward/record.url?scp=85073017961&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/j.celrep.2019.09.001

DO - https://doi.org/10.1016/j.celrep.2019.09.001

M3 - مقالة

C2 - 31618627

SN - 2211-1247

VL - 29

SP - 560-572.e4

JO - Cell Reports

JF - Cell Reports

IS - 3

ER -

Activation of Oncogenic Super-Enhancers Is Coupled with DNA Repair by RAD51

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

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