Activating natural cytotoxicity receptors of natural killer cells in cancer and infection

Joachim Koch; Alexander Steinle; Carsten Watzl; Ofer Mandelboim

doi:10.1016/j.it.2013.01.003

Activating natural cytotoxicity receptors of natural killer cells in cancer and infection

Joachim Koch, Alexander Steinle, Carsten Watzl, Ofer Mandelboim

Department of Immunology and Cancer Research

The Hebrew University of Jerusalem

Research output: Contribution to journal › Review article › peer-review

Abstract

Natural killer (NK) cells are central players in the vertebrate immune system that rapidly eliminate malignantly transformed or infected cells. The natural cytotoxicity receptors (NCRs) NKp30, NKp44, and NKp46 are important mediators of NK cell cytotoxicity, which trigger an immune response on recognition of cognate cellular and viral ligands. Tumour and viral immune escape strategies targeting these receptor-ligand systems impair NK cell cytotoxicity and promote disease. Therefore, a molecular understanding of the function of the NCRs in immunosurveillance is instrumental to discovering novel access points to combat infections and cancer.

Original language	English
Pages (from-to)	182-191
Number of pages	10
Journal	Trends in Immunology
Volume	34
Issue number	4
DOIs	https://doi.org/10.1016/j.it.2013.01.003
State	Published - Apr 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.1016/j.it.2013.01.003

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title = "Activating natural cytotoxicity receptors of natural killer cells in cancer and infection",

abstract = "Natural killer (NK) cells are central players in the vertebrate immune system that rapidly eliminate malignantly transformed or infected cells. The natural cytotoxicity receptors (NCRs) NKp30, NKp44, and NKp46 are important mediators of NK cell cytotoxicity, which trigger an immune response on recognition of cognate cellular and viral ligands. Tumour and viral immune escape strategies targeting these receptor-ligand systems impair NK cell cytotoxicity and promote disease. Therefore, a molecular understanding of the function of the NCRs in immunosurveillance is instrumental to discovering novel access points to combat infections and cancer.",

author = "Joachim Koch and Alexander Steinle and Carsten Watzl and Ofer Mandelboim",

note = "Funding Information: The laboratory of J.K. is supported by institutional funds of the Georg-Speyer-Haus and by grants from LOEWE Center for Cell and Gene Therapy Frankfurt funded by: Hessisches Ministerium f{\"u}r Wissenschaft und Kunst (HMWK) funding reference number: III L 4- 518/17.004 (2010) and the Wilhelm-Sander Stiftung (2010.104.1). The Georg-Speyer-Haus is funded jointly by the German Federal Ministry of Health (BMG) and the Ministry of Higher Education, Research and the Arts of the State of Hessen (HMWK). Research of the laboratory of A.S. is funded by the Deutsche Forschungsgemeinschaft (DFG). The laboratory of C.W. is supported by grants from the DFG and the Bundesministerium f{\"u}r Bildung und Forschung (BMBF). The laboratory of O.M. is supported by the ISF, the ICRF and by the Israeli-ICORE. O.M. is a Crown Professor of Molecular Immunology.",

year = "2013",

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doi = "10.1016/j.it.2013.01.003",

language = "الإنجليزيّة",

volume = "34",

pages = "182--191",

journal = "Trends in Immunology",

issn = "1471-4906",

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number = "4",

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AU - Koch, Joachim

AU - Steinle, Alexander

AU - Watzl, Carsten

AU - Mandelboim, Ofer

N1 - Funding Information: The laboratory of J.K. is supported by institutional funds of the Georg-Speyer-Haus and by grants from LOEWE Center for Cell and Gene Therapy Frankfurt funded by: Hessisches Ministerium für Wissenschaft und Kunst (HMWK) funding reference number: III L 4- 518/17.004 (2010) and the Wilhelm-Sander Stiftung (2010.104.1). The Georg-Speyer-Haus is funded jointly by the German Federal Ministry of Health (BMG) and the Ministry of Higher Education, Research and the Arts of the State of Hessen (HMWK). Research of the laboratory of A.S. is funded by the Deutsche Forschungsgemeinschaft (DFG). The laboratory of C.W. is supported by grants from the DFG and the Bundesministerium für Bildung und Forschung (BMBF). The laboratory of O.M. is supported by the ISF, the ICRF and by the Israeli-ICORE. O.M. is a Crown Professor of Molecular Immunology.

PY - 2013/4

Y1 - 2013/4

N2 - Natural killer (NK) cells are central players in the vertebrate immune system that rapidly eliminate malignantly transformed or infected cells. The natural cytotoxicity receptors (NCRs) NKp30, NKp44, and NKp46 are important mediators of NK cell cytotoxicity, which trigger an immune response on recognition of cognate cellular and viral ligands. Tumour and viral immune escape strategies targeting these receptor-ligand systems impair NK cell cytotoxicity and promote disease. Therefore, a molecular understanding of the function of the NCRs in immunosurveillance is instrumental to discovering novel access points to combat infections and cancer.

AB - Natural killer (NK) cells are central players in the vertebrate immune system that rapidly eliminate malignantly transformed or infected cells. The natural cytotoxicity receptors (NCRs) NKp30, NKp44, and NKp46 are important mediators of NK cell cytotoxicity, which trigger an immune response on recognition of cognate cellular and viral ligands. Tumour and viral immune escape strategies targeting these receptor-ligand systems impair NK cell cytotoxicity and promote disease. Therefore, a molecular understanding of the function of the NCRs in immunosurveillance is instrumental to discovering novel access points to combat infections and cancer.

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U2 - 10.1016/j.it.2013.01.003

DO - 10.1016/j.it.2013.01.003

M3 - مقالة مرجعية

C2 - 23414611

SN - 1471-4906

VL - 34

SP - 182

EP - 191

JO - Trends in Immunology

JF - Trends in Immunology

IS - 4

ER -

Activating natural cytotoxicity receptors of natural killer cells in cancer and infection

Abstract

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