TY - JOUR
T1 - Actin flows mediate a universal coupling between cell speed and cell persistence
AU - Maiuri, Paolo
AU - Rupprecht, Jean-Francois
AU - Wieser, Stefan
AU - Ruprecht, Verena
AU - Benichou, Olivier
AU - Carpi, Nicolas
AU - Coppey, Mathieu
AU - De Beco, Simon
AU - Gov, Nir
AU - Heisenberg, Carl-Philipp
AU - Crespo, Carolina Lage
AU - Lautenschlaeger, Franziska
AU - Le Berre, Maeil
AU - Lennon-Dumenil, Ana-Maria
AU - Raab, Matthew
AU - Thiam, Hawa-Racine
AU - Piel, Matthieu
AU - Sixt, Michael
AU - Voituriez, Raphael
N1 - Fondation pour la Recherche Medicale; Austrian Science Fund (FWF) [T560-B17]; AIRC-IG; PRIN; EMBO ALTF [1163-2010]; ANR [ANR-09-PIRI-0027]; InNaBioSant; ERC [311205-PROMICO, 281556_Leukocyte Forces]; HFSP Program Grant We acknowledge J. Wittbrodt for providing the medaka fish transgenic line and D. Riveline and J.F. Joanny for discussions and comments on the manuscript. The authors greatly acknowledge Lucie Sengmanivong from the Nikon Imaging Centre at Institut Curie-CNRS and Vincent Fraisier from the PICT-IBiSA Lhomond Imaging facility of Institut Curie for their help on microscopy. P.M. was supported by a "Fondation pour la Recherche Medicale" fellowship. V.R. was supported by the Austrian Science Fund (FWF) T560-B17. C.L.C. was supported by grant AIRC-IG and PRIN 2010-2011 to Ruggero Pardi. F.L. was supported by EMBO ALTF 1163-2010. O.B., R.V., and M.P. were supported by ANR (ANR-09-PIRI-0027) and InNaBioSant. M.P. was supported by ERC (311205-PROMICO). M.S. was supported by ERC (281556_Leukocyte Forces) and a HFSP Program Grant.
PY - 2015/4/9
Y1 - 2015/4/9
N2 - Cell movement has essential functions in development, immunity, and cancer. Various cell migration patterns have been reported, but no general rule has emerged so far. Here, we show on the basis of experimental data in vitro and in vivo that cell persistence, which quantifies the straightness of trajectories, is robustly coupled to cell migration speed. We suggest that this universal coupling constitutes a generic law of cell migration, which originates in the advection of polarity cues by an actin cytoskeleton undergoing flows at the cellular scale. Our analysis relies on a theoretical model that we validate by measuring the persistence of cells upon modulation of actin flow speeds and upon optogenetic manipulation of the binding of an actin regulator to actin filaments. Beyond the quantitative prediction of the coupling, the model yields a generic phase diagram of cellular trajectories, which recapitulates the full range of observed migration patterns.
AB - Cell movement has essential functions in development, immunity, and cancer. Various cell migration patterns have been reported, but no general rule has emerged so far. Here, we show on the basis of experimental data in vitro and in vivo that cell persistence, which quantifies the straightness of trajectories, is robustly coupled to cell migration speed. We suggest that this universal coupling constitutes a generic law of cell migration, which originates in the advection of polarity cues by an actin cytoskeleton undergoing flows at the cellular scale. Our analysis relies on a theoretical model that we validate by measuring the persistence of cells upon modulation of actin flow speeds and upon optogenetic manipulation of the binding of an actin regulator to actin filaments. Beyond the quantitative prediction of the coupling, the model yields a generic phase diagram of cellular trajectories, which recapitulates the full range of observed migration patterns.
UR - http://www.scopus.com/inward/record.url?scp=84939937425&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.cell.2015.01.056
DO - https://doi.org/10.1016/j.cell.2015.01.056
M3 - مقالة
SN - 0092-8674
VL - 161
SP - 374
EP - 386
JO - Cell
JF - Cell
IS - 2
ER -