Achieving broad molecular insights into dynamic protein interactions by integrated structural-kinetic approaches

Moran Grossman, Netta Sela-Passwell, Irit Sagi

Research output: Contribution to journalReview articlepeer-review

Abstract

A network of dynamic protein interactions with their protein partners, substrates, and ligands is known to be crucial for biological function. Revealing molecular and structural-based mechanisms at atomic resolution and in real-time is fundamental for achieving a basic understanding of cellular processes. These technically challenging goals may be achieved by combining time-resolved spectroscopic and structural-kinetic tools, thus providing broad insights into specific molecular events over a wide range of timescales. Here we review representative studies utilizing such an integrated real-time structural approach designed to reveal molecular mechanisms underlying protein interactions at atomic resolution.

Original languageEnglish
Pages (from-to)678-685
Number of pages8
JournalCurrent Opinion in Structural Biology
Volume21
Issue number5
DOIs
StatePublished - Oct 2011

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Structural Biology

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