Abstract
Preparing phosphorylated peptides with multiple adjacent phosphorylations is synthetically difficult, leads to β-elimination, results in low yields, and is extremely slow. We combined synthetic chemical methodologies with computational studies and engineering approaches to develop a strategy that takes advantage of fast stirring, high temperature, and a very low concentration of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) to produce multiphosphorylated peptides at an extremely rapid time and high purity.
Original language | English |
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Pages (from-to) | 2492-2497 |
Number of pages | 6 |
Journal | Organic Process Research and Development |
Volume | 26 |
Issue number | 8 |
DOIs | |
State | Published - 19 Aug 2022 |
Keywords
- acceleration
- kinetics
- peptide
- phosphorylation
- solid phase synthesis
All Science Journal Classification (ASJC) codes
- Physical and Theoretical Chemistry
- Organic Chemistry